Examining clinical correlates, treatment outcomes and mediators in young people with comorbid obsessive-compulsive disorder and autism spectrum disorder.
Autism spectrum disorder
Cognitive behaviour therapy
Family accommodation
Insight
Obsessive compulsive disorder
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
24
09
2020
accepted:
21
11
2021
medline:
19
6
2023
pubmed:
17
12
2021
entrez:
16
12
2021
Statut:
ppublish
Résumé
Despite the high comorbidity, surprisingly little is known about the clinical features, treatment prognosis, and treatment mediators for youth with Obsessive-Compulsive Disorder (OCD) and Autism Spectrum Disorder (ASD). This study, the largest to date, compared 172 young people with OCD and ASD (OCD + ASD) to 447 without ASD (OCD) on clinical characteristics, finding those with OCD + ASD were more likely to endorse poorer insight into their OCD, have greater global functional impairment, greater levels of concurrent psychopathology, higher levels of family accommodation and to be on medication. Treatment outcomes following a course of Cognitive Behaviour Therapy with or without medication were explored for a subgroup; 100 young people with OCD + ASD and 223 with OCD. Whilst both groups benefitted from treatment, the OCD + ASD group had significantly poorer treatment outcomes. Greater global functional impairment and being on medication mediated the between-group difference in outcomes. Further research and treatment refinements are needed to improve outcomes for youth with OCD + ASD.
Identifiants
pubmed: 34914003
doi: 10.1007/s00787-021-01921-4
pii: 10.1007/s00787-021-01921-4
pmc: PMC10276061
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1201-1210Subventions
Organisme : Medical Research Council
ID : MR/N001400/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N001400/1
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
Références
J Child Psychol Psychiatry. 2011 Dec;52(12):1261-8
pubmed: 21726224
Aust N Z J Psychiatry. 2010 Dec;44(12):1082-8
pubmed: 20973622
J Am Acad Child Adolesc Psychiatry. 2008 Aug;47(8):921-9
pubmed: 18645422
Clin Child Fam Psychol Rev. 2011 Sep;14(3):302-17
pubmed: 21735077
Am J Psychiatry. 1998 Jan;155(1):102-8
pubmed: 9433346
Child Psychiatry Hum Dev. 2018 Aug;49(4):607-620
pubmed: 29243079
Depress Anxiety. 2013 Aug;30(8):697-708
pubmed: 23389964
Child Psychiatry Hum Dev. 2021 Oct;52(5):916-927
pubmed: 33025371
Arch Gen Psychiatry. 1983 Nov;40(11):1228-31
pubmed: 6639293
J Dev Phys Disabil. 2018 Feb;30(1):69-87
pubmed: 29568212
J Am Acad Child Adolesc Psychiatry. 1997 Jun;36(6):844-52
pubmed: 9183141
J Am Acad Child Adolesc Psychiatry. 2008 Jul;47(7):773-778
pubmed: 18344900
J Abnorm Child Psychol. 2020 Oct;48(10):1313-1323
pubmed: 32683586
J Autism Dev Disord. 2019 Sep;49(9):3602-3610
pubmed: 31134428
J Am Acad Child Adolesc Psychiatry. 2014 Jan;53(1):97-107.e1
pubmed: 24342389
Eur Child Adolesc Psychiatry. 2020 Nov;29(11):1603-1611
pubmed: 32008168
World Psychiatry. 2016 Feb;15(1):80-1
pubmed: 26833615
J Child Psychol Psychiatry. 1995 Jul;36(5):787-92
pubmed: 7559845
Psychiatry Res. 2004 Nov 30;129(1):91-8
pubmed: 15572188
J Clin Psychiatry. 2013 Jul;74(7):685-90
pubmed: 23945445
J Consult Clin Psychol. 2009 Apr;77(2):355-60
pubmed: 19309195
Child Adolesc Psychiatr Clin N Am. 1999 Jul;8(3):445-60
pubmed: 10442225
Compr Psychiatry. 2001 Nov-Dec;42(6):494-7
pubmed: 11704942
Autism. 2020 Jan;24(1):190-199
pubmed: 31187645
Psychiatry Res. 2015 Jul 30;228(1):8-13
pubmed: 25935374
J Autism Dev Disord. 1989 Jun;19(2):185-212
pubmed: 2745388
J Anxiety Disord. 2016 Oct;43:58-69
pubmed: 27632568
J Am Acad Child Adolesc Psychiatry. 2001 Nov;40(11):1337-45
pubmed: 11699809
Expert Rev Neurother. 2012 Feb;12(2):229-38
pubmed: 22288678
Am J Psychiatry. 1995 Mar;152(3):441-3
pubmed: 7864273
J Am Acad Child Adolesc Psychiatry. 2010 Oct;49(10):1024-33; quiz 1086
pubmed: 20855047
J Psychopathol Behav Assess. 2009 Mar;31(1):38-46
pubmed: 21743772
J Child Adolesc Psychopharmacol. 2003;13 Suppl 1:S61-9
pubmed: 12880501
Br J Psychiatry. 2001 Oct;179:324-9
pubmed: 11581112
J Am Acad Child Adolesc Psychiatry. 2012 Jan;51(1):98-113
pubmed: 22176943
J Autism Dev Disord. 1994 Oct;24(5):659-85
pubmed: 7814313
JAMA Psychiatry. 2018 Jan 1;75(1):47-55
pubmed: 29141084