A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates.

Animals Antibodies, Neutralizing Antibodies, Viral COVID-19 COVID-19 Vaccines Ferritins Humans Immunity Macaca mulatta Nanoparticles SARS-CoV-2 Spike Glycoprotein, Coronavirus

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
16 Feb 2022
Historique:
pubmed: 17 12 2021
medline: 25 2 2022
entrez: 16 12 2021
Statut: ppublish

Résumé

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants stresses the continued need for next-generation vaccines that confer broad protection against coronavirus disease 2019 (COVID-19). We developed and evaluated an adjuvanted SARS-CoV-2 spike ferritin nanoparticle (SpFN) vaccine in nonhuman primates. High-dose (50 μg) SpFN vaccine, given twice 28 days apart, induced a Th1-biased CD4 T cell helper response and elicited neutralizing antibodies against SARS-CoV-2 wild-type and variants of concern, as well as against SARS-CoV-1. These potent humoral and cell-mediated immune responses translated into rapid elimination of replicating virus in the upper and lower airways and lung parenchyma of nonhuman primates following high-dose SARS-CoV-2 respiratory challenge. The immune response elicited by SpFN vaccination and resulting efficacy in nonhuman primates supports the utility of SpFN as a vaccine candidate for SARS-causing betacoronaviruses.

Identifiants

DOI: 10.1126/scitranslmed.abi5735 PMID: 34914540
pubmed: 34914540
doi: 10.1126/scitranslmed.abi5735
pii: 10.1126/scitranslmed.abi5735
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
COVID-19 Vaccines 0
Spike Glycoprotein, Coronavirus 0
Ferritins 9007-73-2

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabi5735

Auteurs

M Gordon Joyce (MG)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0002-6808-7232

Hannah A D King (HAD)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-7575-198X

Ines Elakhal-Naouar (I)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-6811-6534

Aslaa Ahmed (A)

Viral Diseases Branch, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-3093-4982

Kristina K Peachman (KK)

Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-8568-1439

Camila Macedo Cincotta (C)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-1495-1133

Caroline Subra (C)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-5272-0972

Rita E Chen (RE)

Department of Medicine, Washington University, St. Louis, MO 63130, USA.
Department of Pathology and Immunology, Washington University, St. Louis, MO 63130, USA.
ORCID: 0000-0002-5100-7750

Paul V Thomas (PV)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Wei-Hung Chen (WH)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Rajeshwer S Sankhala (RS)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Agnes Hajduczki (A)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Elizabeth J Martinez (EJ)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0002-7755-7056

Caroline E Peterson (CE)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0002-6087-7301

William C Chang (WC)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0003-4967-6426

Misook Choe (M)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0003-0243-5203

Clayton Smith (C)

Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

Parker J Lee (PJ)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0001-9601-8165

Jarrett A Headley (JA)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0001-5809-5485

Mekdi G Taddese (MG)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Hanne A Elyard (HA)

Bioqual, Rockville, MD 20850, USA.

Anthony Cook (A)

Bioqual, Rockville, MD 20850, USA.

Alexander Anderson (A)

U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Oak Ridge Institute of Science and Education, Oak Ridge, TN 37830, USA.
ORCID: 0000-0002-0000-7734

Kathryn McGuckin Wuertz (K)

U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-2658-6284

Ming Dong (M)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.

Isabella Swafford (I)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-8638-2772

James Brett Case (JB)

Department of Medicine, Washington University, St. Louis, MO 63130, USA.
ORCID: 0000-0001-7331-5511

Jeffrey R Currier (JR)

Viral Diseases Branch, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-5696-0268

Kerri G Lal (KG)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.

Sebastian Molnar (S)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-0171-8001

Manoj S Nair (MS)

Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
ORCID: 0000-0002-5994-3957

Vincent Dussupt (V)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-8579-6356

Sharon P Daye (SP)

Center for Infectious Diseases Research, WRAIR, Silver Spring, MD 20910, USA.

Xiankun Zeng (X)

Division of Pathology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
ORCID: 0000-0003-3526-8755

Erica K Barkei (EK)

Veterinary Pathology Department, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-1120-7894

Hilary M Staples (HM)

Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.

Kendra Alfson (K)

Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
ORCID: 0000-0001-6031-5360

Ricardo Carrion (R)

Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
ORCID: 0000-0001-7046-7683

Shelly J Krebs (SJ)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-1136-1760

Dominic Paquin-Proulx (D)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-1407-3414

Nicos Karasavva (N)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-7372-4294

Victoria R Polonis (VR)

U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.

Linda L Jagodzinski (LL)

Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-3142-8643

Mihret F Amare (MF)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0002-2696-6116

Sandhya Vasan (S)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-6378-6288

Paul T Scott (PT)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
ORCID: 0000-0002-2348-4541

Yaoxing Huang (Y)

Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
ORCID: 0000-0001-6270-1644

David D Ho (DD)

Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
ORCID: 0000-0003-1627-149X

Natalia de Val (N)

Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
ORCID: 0000-0002-1506-2023

Michael S Diamond (MS)

Department of Medicine, Washington University, St. Louis, MO 63130, USA.
Department of Pathology and Immunology, Washington University, St. Louis, MO 63130, USA.
Department of Molecular Microbiology, Washington University, St. Louis, MO 63130, USA.
ORCID: 0000-0002-8791-3165

Mark G Lewis (MG)

Bioqual, Rockville, MD 20850, USA.
ORCID: 0000-0001-7852-0135

Mangala Rao (M)

U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-9553-4969

Gary R Matyas (GR)

U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0002-2074-2373

Gregory D Gromowski (GD)

Viral Diseases Branch, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-4576-4277

Sheila A Peel (SA)

Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.

Nelson L Michael (NL)

Center for Infectious Diseases Research, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0001-5882-5548

Diane L Bolton (DL)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
ORCID: 0000-0003-1897-499X

Kayvon Modjarrad (K)

Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la COVID-19 › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Ferritines › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › A SARS-CoV-2 ferritin nanoparticle vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › A SARS-CoV-2 ferritin nanoparticle vaccine...