Characterization and diabetic wound healing benefits of protein-polysaccharide complexes isolated from an animal ethno-medicine Periplaneta americana L.
Amino Acids
/ chemistry
Animals
Biocompatible Materials
Cell Line
Chemical Phenomena
Diabetes Mellitus, Experimental
Humans
Insect Proteins
/ chemistry
Macromolecular Substances
/ chemistry
Medicine, Traditional
Mice
Monosaccharides
/ chemistry
Periplaneta
/ chemistry
Polysaccharides
/ chemistry
Spectrum Analysis
Wound Healing
Angiogenesis
Diabetic
Periplaneta americana L.
Protein-polysaccharide complexes
Wound healing
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Jan 2022
15 Jan 2022
Historique:
received:
13
10
2021
revised:
30
11
2021
accepted:
04
12
2021
pubmed:
17
12
2021
medline:
26
3
2022
entrez:
16
12
2021
Statut:
ppublish
Résumé
Periplaneta americana L. (PA), a type of animal medicine, has been widely used for wound healing in clinical settings. In order to further investigate the bioactive wound healing substances in PA, crude PA protein-polysaccharide complexes were further purified by cellulose DE-52 and Sephadex G100 chromatography in succession. Among these isolated fractions, two fractions eluted by 0.3 M and 0.5 M NaCl with the higher yield, respectively named PaPPc2 and PaPPc3 respectively, were chosen for the wound healing experiments. Mediated by HPGPC, amino acid and monosaccharide composition analysis, circular dichroism spectrum, glycosylation type, FT-IR, and
Identifiants
pubmed: 34914909
pii: S0141-8130(21)02634-9
doi: 10.1016/j.ijbiomac.2021.12.018
pii:
doi:
Substances chimiques
Amino Acids
0
Biocompatible Materials
0
Insect Proteins
0
Macromolecular Substances
0
Monosaccharides
0
Polysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
466-474Informations de copyright
Copyright © 2021. Published by Elsevier B.V.