Ultrasound-Based Renal Parenchymal Area and Kidney Function Decline in Infants With Congenital Anomalies of the Kidney and Urinary Tract.
CKD
children
congenital anomalies
kidney
renal parenchymal area
urinary tract
Journal
Seminars in nephrology
ISSN: 1558-4488
Titre abrégé: Semin Nephrol
Pays: United States
ID NLM: 8110298
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
entrez:
17
12
2021
pubmed:
18
12
2021
medline:
15
4
2022
Statut:
ppublish
Résumé
Congenital anomalies of the kidney and urinary tract are the leading cause of chronic kidney disease in children. Noninvasive imaging biomarkers that predict chronic kidney disease progression in early infancy are needed. We performed a pilot study nested in the prospective Chronic Kidney Disease in Children cohort study to determine the association between renal parenchymal area (RPA) on first post-natal renal ultrasound and change in estimated glomerular filtration rate (eGFR) in children with congenital anomalies of the kidney and urinary tract. Among 14 participants, 78.6% were males, the median age at the time of the ultrasound was 3.4 months (interquartile range, 1.3-7.9 mo), and the median total RPA z-score at baseline was -1.01 (interquartile range, -2.39 to 0.52). After a median follow-up period of 7.4 years (interquartile range, 6.8-8.2 y), the eGFR decreased from a median of 49.4 mL/min per 1.73 m
Identifiants
pubmed: 34916003
pii: S0270-9295(21)00121-2
doi: 10.1016/j.semnephrol.2021.09.004
pmc: PMC9036416
mid: NIHMS1795664
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
427-433Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK066143
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK066174
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK066116
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK117297
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007006
Pays : United States
Organisme : NIDDK NIH HHS
ID : P50 DK114786
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK082194
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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