Symmetric activation and modulation of the human calcium-sensing receptor.
activation mechanism
allosteric modulation
calcium-sensing receptor
cryo-EM structure
symmetry
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
accepted:
10
11
2021
entrez:
17
12
2021
pubmed:
18
12
2021
medline:
13
1
2022
Statut:
ppublish
Résumé
The human extracellular calcium-sensing (CaS) receptor controls plasma Ca
Identifiants
pubmed: 34916296
pii: 2115849118
doi: 10.1073/pnas.2115849118
pmc: PMC8713963
pii:
doi:
Substances chimiques
Receptors, Calcium-Sensing
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM141871
Pays : United States
Organisme : Medical Research Council
ID : MC_U105184326
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM107462
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM029169
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103310
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM116799
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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