Contributions of sex, depression, and cognition on brain connectivity dynamics in Parkinson's disease.

Journal

NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390

Informations de publication

Date de publication:
16 Dec 2021
Historique:
received: 16 08 2020
accepted: 19 11 2021
entrez: 17 12 2021
pubmed: 18 12 2021
medline: 18 12 2021
Statut: epublish

Résumé

Alterations in time-varying functional connectivity (FC) have been found in Parkinson's disease (PD) patients. To date, very little is known about the influence of sex on brain FC in PD patients and how this could be related to disease severity. The first objective was to evaluate the influence of sex on dynamic FC characteristics in PD patients and healthy controls (HC), while the second aim was to investigate the temporal patterns of dynamic connectivity related to PD motor and non-motor symptoms. Ninety-nine PD patients and sixty-two HC underwent a neuropsychological and clinical assessment. Rs-fMRI and T1-weighted MRI were also acquired. Dynamic FC analyses were performed in the GIFT toolbox. Dynamic FC analyses identified two States: State I, characterized by within-network positive coupling; and State II that showed between-network connectivity, mostly involving somatomotor and visual networks. Sex differences were found in dynamic indexes in HC but these differences were not observed in PD. Hierarchical clustering analysis identified three phenotypically distinct PD subgroups: (1) Subgroup A was characterized by mild motor symptoms; (2) Subgroup B was characterized by depressive and motor symptoms; (3) Subgroup C was characterized by cognitive and motor symptoms. Results revealed that changes in the temporal properties of connectivity were related to the motor/non-motor outcomes of PD severity. Findings suggest that while in HC sex differences may play a certain role in dynamic connectivity patterns, in PD patients, these effects may be overcome by the neurodegenerative process. Changes in the temporal properties of connectivity in PD were mainly related to the clinical markers of PD severity.

Identifiants

DOI: 10.1038/s41531-021-00257-9 PMID: 34916518 PMC: PMC8677758
pubmed: 34916518
doi: 10.1038/s41531-021-00257-9
pii: 10.1038/s41531-021-00257-9
pmc: PMC8677758
doi:

Types de publication

Journal Article

Langues

eng

Pagination

117

Subventions

Organisme : Canadian HIV Trials Network, Canadian Institutes of Health Research (Réseau canadien pour les essais VIH des IRSC)
ID : MOP-136778

Informations de copyright

© 2021. The Author(s).

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Auteurs

Maria Diez-Cirarda (M)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. maria.diecirarda@gmail.com.
E.J. Safra Parkinson Disease Program & Movement Disorder Unit, Neurology Division; Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada. maria.diecirarda@gmail.com.
Neurodegenerative Diseases Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain. maria.diecirarda@gmail.com.
ORCID: 0000-0001-6768-189X

Iñigo Gabilondo (I)

Neurodegenerative Diseases Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
IKERBASQUE, The Basque Foundation for Science, Bilbao, Spain.
ORCID: 0000-0001-6045-2840

Naroa Ibarretxe-Bilbao (N)

Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Spain.

Juan Carlos Gómez-Esteban (JC)

Neurodegenerative Diseases Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Neurology Department, Cruces University Hospital, Barakaldo, Spain.

Jinhee Kim (J)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
E.J. Safra Parkinson Disease Program & Movement Disorder Unit, Neurology Division; Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada.
ORCID: 0000-0002-1019-7455

Olaia Lucas-Jiménez (O)

Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Spain.
ORCID: 0000-0002-7715-3764

Rocio Del Pino (R)

Neurodegenerative Diseases Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.

Javier Peña (J)

Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Spain.
ORCID: 0000-0002-0041-7020

Natalia Ojeda (N)

Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Spain.

Alexander Mihaescu (A)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
E.J. Safra Parkinson Disease Program & Movement Disorder Unit, Neurology Division; Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada.

Mikaeel Valli (M)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
E.J. Safra Parkinson Disease Program & Movement Disorder Unit, Neurology Division; Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada.
ORCID: 0000-0002-4059-2333

Maria Angeles Acera (MA)

Neurodegenerative Diseases Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.

Alberto Cabrera-Zubizarreta (A)

OSATEK, MR Unit, Hospital of Galdakao, Galdakao, Bilbao, Spain.

Maria Angeles Gómez-Beldarrain (MA)

Neurology Service, Hospital of Galdakao, Galdakao, Bilbao, Spain.

Antonio P Strafella (AP)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. Antonio.Strafella@camh.ca.
E.J. Safra Parkinson Disease Program & Movement Disorder Unit, Neurology Division; Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada. Antonio.Strafella@camh.ca.

Classifications MeSH