Deep dissection of the antiviral immune profile of patients with COVID-19.
Adaptive Immunity
/ immunology
Adult
Aged
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
COVID-19
/ immunology
COVID-19 Vaccines
/ immunology
Coronavirus Nucleocapsid Proteins
/ genetics
Female
Humans
Immunity, Humoral
/ immunology
Immunoglobulin G
/ genetics
Male
Middle Aged
Mutation
SARS-CoV-2
/ genetics
Spike Glycoprotein, Coronavirus
/ genetics
Viral Proteins
/ genetics
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
16 12 2021
16 12 2021
Historique:
received:
18
03
2021
accepted:
02
11
2021
entrez:
17
12
2021
pubmed:
18
12
2021
medline:
1
1
2022
Statut:
epublish
Résumé
In light of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants potentially undermining humoral immunity, it is important to understand the fine specificity of the antiviral antibodies. We screened 20 COVID-19 patients for antibodies against 9 different SARS-CoV-2 proteins observing responses against the spike (S) proteins, the receptor-binding domain (RBD), and the nucleocapsid (N) protein which were of the IgG1 and IgG3 subtypes. Importantly, mutations which typically occur in the B.1.351 "South African" variant, significantly reduced the binding of anti-RBD antibodies. Nine of 20 patients were critically ill and were considered high-risk (HR). These patients showed significantly higher levels of transforming growth factor beta (TGF-β) and myeloid-derived suppressor cells (MDSC), and lower levels of CD4
Identifiants
pubmed: 34916602
doi: 10.1038/s42003-021-02852-1
pii: 10.1038/s42003-021-02852-1
pmc: PMC8677724
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Coronavirus Nucleocapsid Proteins
0
Immunoglobulin G
0
Spike Glycoprotein, Coronavirus
0
Viral Proteins
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1389Informations de copyright
© 2021. The Author(s).
Références
Cell. 2020 Jul 9;182(1):73-84.e16
pubmed: 32425270
Nat Rev Immunol. 2008 Jan;8(1):34-47
pubmed: 18064051
Nat Med. 2020 Jun;26(6):845-848
pubmed: 32350462
J Gen Virol. 2002 Sep;83(Pt 9):2091-2108
pubmed: 12185262
Science. 2020 May 1;368(6490):489-493
pubmed: 32179701
Int J Biol Sci. 2020 Apr 21;16(11):1954-1955
pubmed: 32398962
Eur J Immunol. 2020 Dec;50(12):2013-2024
pubmed: 33080068
Science. 2020 Aug 21;369(6506):956-963
pubmed: 32540903
Cell. 2021 Mar 4;184(5):1171-1187.e20
pubmed: 33621484
Clin Infect Dis. 2020 Sep 12;71(6):1400-1409
pubmed: 32270184
Chest. 2020 Jul;158(1):97-105
pubmed: 32304772
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Cell Death Dis. 2020 Oct 27;11(10):921
pubmed: 33110074
Nat Commun. 2021 Mar 30;12(1):1961
pubmed: 33785765
Cell Rep Med. 2020 Jun 23;1(3):100040
pubmed: 32835303
Nature. 2020 Aug;584(7819):120-124
pubmed: 32454512
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Nature. 2021 Mar;591(7848):124-130
pubmed: 33494096
Nature. 2021 May;593(7857):142-146
pubmed: 33780970
Front Immunol. 2020 Sep 30;11:582010
pubmed: 33117392
Nat Med. 2020 Apr;26(4):453-455
pubmed: 32284614
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
N Engl J Med. 2021 Apr 22;384(16):1576-1577
pubmed: 33596348
Nat Commun. 2020 May 4;11(1):2251
pubmed: 32366817
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
Nat Med. 2020 Aug;26(8):1200-1204
pubmed: 32555424
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
J Med Virol. 2020 Oct;92(10):1735-1738
pubmed: 32243608
JAMA. 2020 May 26;323(20):2052-2059
pubmed: 32320003
Science. 2020 Aug 7;369(6504):650-655
pubmed: 32571838
Nature. 2013 Nov 28;503(7477):535-8
pubmed: 24172901
Cell Mol Immunol. 2020 Jul;17(7):773-775
pubmed: 32467617
Leukemia. 2020 Jan;34(1):317-321
pubmed: 31409922
Nat Med. 2021 Apr;27(4):620-621
pubmed: 33558724
Science. 2020 Nov 27;370(6520):
pubmed: 32994364
N Engl J Med. 2021 Feb 11;384(6):533-540
pubmed: 33369366
Blood Adv. 2020 Oct 13;4(19):4864-4868
pubmed: 33031540
Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9
pubmed: 33259788
Cell Death Differ. 2020 Nov;27(11):3196-3207
pubmed: 32514047
N Engl J Med. 2020 Dec 17;383(25):2427-2438
pubmed: 32991794
Nature. 2020 Aug;584(7821):443-449
pubmed: 32668443
Sci Rep. 2020 Nov 26;10(1):20731
pubmed: 33244144
J Clin Invest. 2020 Nov 2;130(11):6141-6150
pubmed: 32764200
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Nat Med. 2021 Mar;27(3):440-446
pubmed: 33531709
Nat Commun. 2020 Mar 27;11(1):1620
pubmed: 32221306
Eur Respir J. 2020 May 14;55(5):
pubmed: 32217650
Cell. 2020 Nov 12;183(4):1024-1042.e21
pubmed: 32991844
Eur J Immunol. 2020 Dec;50(12):1998-2012
pubmed: 33073359
PLoS One. 2020 Nov 17;15(11):e0241955
pubmed: 33201896
N Engl J Med. 2021 May 13;384(19):1824-1835
pubmed: 33440088
N Engl J Med. 2020 Dec 17;383(25):2439-2450
pubmed: 33053279
N Engl J Med. 2021 Jan 7;384(1):80-82
pubmed: 33270381
Nat Commun. 2020 Nov 27;11(1):6044
pubmed: 33247152
Trends Immunol. 2011 Jan;32(1):19-25
pubmed: 21067974