Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy.
Inter-observer variability
Proton therapy
Range uncertainty
Sensitivity analysis
Setup uncertainty
Journal
Physics and imaging in radiation oncology
ISSN: 2405-6316
Titre abrégé: Phys Imaging Radiat Oncol
Pays: Netherlands
ID NLM: 101704276
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
30
09
2021
revised:
16
11
2021
accepted:
16
11
2021
entrez:
17
12
2021
pubmed:
18
12
2021
medline:
18
12
2021
Statut:
epublish
Résumé
Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 × 10
Identifiants
pubmed: 34917780
doi: 10.1016/j.phro.2021.11.005
pii: S2405-6316(21)00069-5
pmc: PMC8645917
doi:
Types de publication
Journal Article
Langues
eng
Pagination
117-120Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
CB holds research grants from Elekta, Brainlab, Viewray and C-Rad without any relation to the research described here. The remaining authors declare that they have no competing interest.
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