Do alterations in pulmonary vascular tone result in changes in central blood volumes? An experimental study.
Blood volume
Dogs
Double-indicator transpulmonary thermo-dye dilution
Hypoxia
Mean systemic filling pressure
Preload
Pulmonary vascular tone
Journal
Intensive care medicine experimental
ISSN: 2197-425X
Titre abrégé: Intensive Care Med Exp
Pays: Germany
ID NLM: 101645149
Informations de publication
Date de publication:
17 Dec 2021
17 Dec 2021
Historique:
received:
23
06
2021
accepted:
01
11
2021
entrez:
17
12
2021
pubmed:
18
12
2021
medline:
18
12
2021
Statut:
epublish
Résumé
The effects of selective pulmonary vascular tone alterations on cardiac preload have not been previously examined. Therefore, we evaluated whether changing pulmonary vascular tone either by hypoxia or the inhalation of aerosolized prostacyclin (PGI In a randomized controlled animal study in 6 spontaneously breathing dogs, pulmonary vascular tone was increased by controlled moderate hypoxia (FiO During hypoxia, mean pulmonary artery pressure (PAP) increased from median [IQR] 12 [8-15] to 19 [17-25] mmHg (p < 0.05). ITBV, PBV and their ratio with Vd In spontaneously breathing dogs, changes in pulmonary vascular tone altered PAP but had no effect on cardiac output, central blood volumes or their relation to circulating blood volume, nor on Pmsa and Pvr. These observations suggest that cardiac preload is preserved despite substantial alterations in right ventricular afterload.
Sections du résumé
BACKGROUND
BACKGROUND
The effects of selective pulmonary vascular tone alterations on cardiac preload have not been previously examined. Therefore, we evaluated whether changing pulmonary vascular tone either by hypoxia or the inhalation of aerosolized prostacyclin (PGI
METHODS
METHODS
In a randomized controlled animal study in 6 spontaneously breathing dogs, pulmonary vascular tone was increased by controlled moderate hypoxia (FiO
RESULTS
RESULTS
During hypoxia, mean pulmonary artery pressure (PAP) increased from median [IQR] 12 [8-15] to 19 [17-25] mmHg (p < 0.05). ITBV, PBV and their ratio with Vd
CONCLUSIONS
CONCLUSIONS
In spontaneously breathing dogs, changes in pulmonary vascular tone altered PAP but had no effect on cardiac output, central blood volumes or their relation to circulating blood volume, nor on Pmsa and Pvr. These observations suggest that cardiac preload is preserved despite substantial alterations in right ventricular afterload.
Identifiants
pubmed: 34918178
doi: 10.1186/s40635-021-00421-8
pii: 10.1186/s40635-021-00421-8
pmc: PMC8677875
doi:
Types de publication
Journal Article
Langues
eng
Pagination
59Informations de copyright
© 2021. The Author(s).
Références
Br J Anaesth. 2016 Jan;116(1):46-53
pubmed: 26515805
Crit Care Med. 2013 Jan;41(1):255-62
pubmed: 23269130
Intensive Care Med. 1999 Dec;25(12):1413-20
pubmed: 10660850
Pediatr Res. 1994 Jan;35(1):20-4
pubmed: 8134193
Eur Heart J. 1982 Oct;3 Suppl C:39-43
pubmed: 6756922
J Clin Invest. 1962 Jul;41:1553-63
pubmed: 14453095
Intensive Care Med. 2012 Sep;38(9):1452-60
pubmed: 22584797
Transfus Sci. 1997 Sep;18(3):409-23
pubmed: 10175155
Pediatr Crit Care Med. 2010 Mar;11(2 Suppl):S41-5
pubmed: 20216163
J Crit Care. 2013 Oct;28(5):880.e9-15
pubmed: 23731817
Intensive Care Med. 1997 Feb;23(2):146-58
pubmed: 9068999
Anesthesiology. 2015 Apr;122(4):932-46
pubmed: 25587641
Intensive Care Med. 2001 Apr;27(4):767-74
pubmed: 11398706
Crit Care Med. 2013 Jan;41(1):143-50
pubmed: 23128382
Compr Physiol. 2012 Jan 1;2(1):295-319
pubmed: 23487595
J Clin Monit Comput. 2018 Feb;32(1):73-80
pubmed: 28210935
Acta Physiol Scand. 1997 Oct;161(2):177-86
pubmed: 9366960
J Appl Physiol. 1975 May;38(5):811-6
pubmed: 1126889
Intensive Care Med. 2015 Feb;41(2):265-72
pubmed: 25567379
J Appl Physiol (1985). 1987 Jul;63(1):58-65
pubmed: 3624150
Eur J Anaesthesiol. 2002 Jun;19(6):428-35
pubmed: 12094917
Crit Care. 2012 Oct 29;16(5):236
pubmed: 23106914
Am J Physiol. 1977 Jan;232(1):H67-72
pubmed: 835722
Intensive Care Med. 2000 May;26(5):601-7
pubmed: 10923736
Anesthesiology. 1968 Mar-Apr;29(2):314-26
pubmed: 5635884
Exp Physiol. 2008 Jan;93(1):141-7
pubmed: 17965142
Anesthesiology. 1994 Jul;81(1):76-86
pubmed: 8042813
PLoS Biol. 2020 Jul 14;18(7):e3000411
pubmed: 32663221
J Crit Care. 1994 Jun;9(2):124-33
pubmed: 7920979