Host-pathogen interactions: The role of Pseudomonas aeruginosa exotoxin A in modulation of Galleria mellonella immune response.
Galleria mellonella
Host-pathogen interactions
Immune response
Pseudomonas aeruginosa
exotoxin A
Journal
Journal of invertebrate pathology
ISSN: 1096-0805
Titre abrégé: J Invertebr Pathol
Pays: United States
ID NLM: 0014067
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
17
08
2021
revised:
07
12
2021
accepted:
10
12
2021
pubmed:
18
12
2021
medline:
27
1
2022
entrez:
17
12
2021
Statut:
ppublish
Résumé
The role of Pseudomonas aeruginosa exotoxin A in the modulation of humoral immune response parameters in the hemolymph of Galleria mellonella larvae was investigated. Our results indicate that exoA can play a role of a virulence factor by inhibiting insect PO, lysozyme, and antibacterial activity and decreasing the apoLp-III protein level significantly. No peptide bands with molecular mass below 6.5 kDa were detected in the hemolymph of exoA-treated larvae. We provided evidence for involvement of exoA in the pathogenicity of P. aeruginosa against G. mellonella and the usefulness of the insect as a model for analysis of P. aeruginosa toxins.
Identifiants
pubmed: 34919944
pii: S0022-2011(21)00173-7
doi: 10.1016/j.jip.2021.107706
pii:
doi:
Substances chimiques
Bacterial Toxins
0
Exotoxins
0
Virulence Factors
0
ADP Ribose Transferases
EC 2.4.2.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107706Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.