Recent advancements and application of in vitro models for predicting inhalation toxicity in humans.
In vitro models
Inhalation toxicity
Organ-on-a-chip
Respiratory
Toxicogenomics
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
22
06
2021
revised:
20
11
2021
accepted:
10
12
2021
pubmed:
18
12
2021
medline:
10
2
2022
entrez:
17
12
2021
Statut:
ppublish
Résumé
Animals have been indispensable in testing chemicals that can pose a risk to human health, including those delivered by inhalation. In recent years, the combination of societal debate on the use of animals in research and testing, the drive to continually enhance testing methodologies, and technology advancements have prompted a range of initiatives to develop non-animal alternative approaches for toxicity testing. In this review, we discuss emerging in vitro techniques being developed for the testing of inhaled compounds. Advanced tissue models that are able to recreate the human response to toxic exposures alongside examples of their ability to complement in vivo techniques are described. Furthermore, technology being developed that can provide multi-organ toxicity assessments are discussed.
Identifiants
pubmed: 34920082
pii: S0887-2333(21)00224-1
doi: 10.1016/j.tiv.2021.105299
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105299Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.