Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans.
Mink
SARS-CoV-2
Spill-over
Transmission
Zoonoses
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN: 1469-0691
Titre abrégé: Clin Microbiol Infect
Pays: England
ID NLM: 9516420
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
05
06
2021
revised:
27
11
2021
accepted:
01
12
2021
pubmed:
18
12
2021
medline:
16
3
2022
entrez:
17
12
2021
Statut:
ppublish
Résumé
This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. Next-generation sequencing and a bioinformatic approach were applied to analyse the data. In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others. Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.
Identifiants
pubmed: 34920116
pii: S1198-743X(21)00698-4
doi: 10.1016/j.cmi.2021.12.001
pmc: PMC8673923
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
451.e1-451.e4Informations de copyright
Copyright © 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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