Dissecting the Oncogenic Roles of Keratin 17 in the Hallmarks of Cancer.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
received:
30
07
2021
revised:
08
11
2021
accepted:
14
12
2021
pubmed:
19
12
2021
medline:
6
4
2022
entrez:
18
12
2021
Statut:
ppublish
Résumé
There is an unmet need to identify and validate tumor-specific therapeutic targets to enable more effective treatments for cancer. Heterogeneity in patient clinical characteristics as well as biological and genetic features of tumors present major challenges for the optimization of therapeutic interventions, including the development of novel and more effective precision medicine. The expression of keratin 17 (K17) is a hallmark of the most aggressive forms of cancer across a wide range of anatomical sites and histological types. K17 correlates with shorter patient survival, predicts resistance to specific chemotherapeutic agents, and harbors functional domains that suggest it could be therapeutically targeted. Here, we explore the role of K17 in the hallmarks of cancer and summarize evidence to date for K17-mediated mechanisms involved in each hallmark, elucidating functional roles that warrant further investigation to guide the development of novel therapeutic strategies.
Identifiants
pubmed: 34921015
pii: 0008-5472.CAN-21-2522
doi: 10.1158/0008-5472.CAN-21-2522
pmc: PMC9016724
mid: NIHMS1797836
doi:
Substances chimiques
Antineoplastic Agents
0
KRT17 protein, human
0
Keratin-17
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1159-1166Subventions
Organisme : NCI NIH HHS
ID : R00 CA226342
Pays : United States
Informations de copyright
©2021 The Authors; Published by the American Association for Cancer Research.
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