Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer.

Adult Biomarkers, Pharmacological / analysis Biomarkers, Tumor / analysis DNA Methylation / genetics Female Humans Male Middle Aged Neoadjuvant Therapy / methods Prognosis Proportional Hazards Models Triple Negative Breast Neoplasms / drug therapy
DNA methylation Epigenetics Methylome Neoadjuvant chemotherapy Triple-negative breast cancer

Journal

Clinical epigenetics
ISSN: 1868-7083
Titre abrégé: Clin Epigenetics
Pays: Germany
ID NLM: 101516977

Informations de publication

Date de publication:
18 12 2021
Historique:
received: 24 09 2021
accepted: 07 12 2021
entrez: 19 12 2021
pubmed: 20 12 2021
medline: 1 2 2022
Statut: epublish

Résumé

Neoadjuvant chemotherapy (NAC) is used to treat triple-negative breast cancer (TNBC) prior to resection. Biomarkers that accurately predict a patient's response to NAC are needed to individualise therapy and avoid chemotoxicity from unnecessary chemotherapy. We performed whole-genome DNA methylation profiling on diagnostic TNBC biopsy samples from the Sequential Evaluation of Tumours Undergoing Preoperative (SETUP) NAC study. We found 9 significantly differentially methylated regions (DMRs) at diagnosis which were associated with response to NAC. We show that 4 of these DMRs are associated with TNBC overall survival (P < 0.05). Our results highlight the potential of DNA methylation biomarkers for predicting NAC response in TNBC.

Identifiants

DOI: 10.1186/s13148-021-01210-6 PMID: 34922619 PMC: PMC8684655
pubmed: 34922619
doi: 10.1186/s13148-021-01210-6
pii: 10.1186/s13148-021-01210-6
pmc: PMC8684655
doi:

Substances chimiques

Biomarkers, Pharmacological 0
Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

226

Subventions

Organisme : National Health and Medical Research Council
ID : 1106870
Organisme : National Health and Medical Research Council
ID : 1063559
Organisme : National Health and Medical Research Council
ID : 1156408
Organisme : National Breast Cancer Foundation
ID : IIRS-18-137
Organisme : Cancer Council NSW
ID : RG-18-09

Informations de copyright

© 2021. The Author(s).

Références

Breast Cancer Res Treat. 2012 Apr;132(3):1049-62
pubmed: 22198468
Clin Epigenetics. 2019 Feb 20;11(1):33
pubmed: 30786922
PLoS Med. 2010 May 25;7(5):e1000279
pubmed: 20520800
Nat Commun. 2015 Feb 02;6:5899
pubmed: 25641231
Mol Med Rep. 2017 Oct;16(4):3777-3782
pubmed: 28731140
Genome Biol. 2016 Oct 7;17(1):208
pubmed: 27717381
Breast Cancer Res. 2014 Apr 24;16(2):R44
pubmed: 24762066
NPJ Precis Oncol. 2019 Aug 29;3:21
pubmed: 31482136
EMBO J. 2020 Oct 1;39(19):e104063
pubmed: 32790115
J Clin Oncol. 2008 Mar 10;26(8):1275-81
pubmed: 18250347

Auteurs

Braydon Meyer (B)

Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.

Samuel Clifton (S)

Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.

Warwick Locke (W)

Molecular Diagnostics Solutions, CSIRO Health and Biosecurity, New South Wales, North Ryde, 2113, Australia.

Phuc-Loi Luu (PL)

Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia.

Qian Du (Q)

Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia.

Dilys Lam (D)

Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.

Nicola J Armstrong (NJ)

Department of Mathematics and Statistics, Curtin University, Perth, WA, 6103, Australia.

Beena Kumar (B)

Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Monash Health Pathology, Monash Health, Victoria, 3168, Australia.
Monash University, Melbourne, VIC, 3168, Australia.

Niantao Deng (N)

St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia.
Cancer Research Theme, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.

Kate Harvey (K)

Cancer Research Theme, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.

Alex Swarbrick (A)

St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia.
Cancer Research Theme, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.

Vinod Ganju (V)

Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.

Susan J Clark (SJ)

Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. s.clark@garvan.org.au.
St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia. s.clark@garvan.org.au.

Ruth Pidsley (R)

Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. r.pidsley@garvan.org.au.
St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia. r.pidsley@garvan.org.au.

Clare Stirzaker (C)

Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia. c.stirzaker@garvan.org.au.
St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia. c.stirzaker@garvan.org.au.
ORCID: 0000-0001-5601-3140

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Identification of DNA methylation biomarkers...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Biomarqueurs pharmacologiques › Identification of DNA methylation biomarkers...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Identification of DNA methylation biomarkers...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Identification of DNA methylation biomarkers...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of DNA methylation biomarkers...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Identification of DNA methylation biomarkers...
questionsmedicales.fr › Thérapeutique › Association thérapeutique › Traitement néoadjuvant › Identification of DNA methylation biomarkers...
questionsmedicales.fr › Diagnostic › Pronostic › Identification of DNA methylation biomarkers...
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