Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats.

Animals Membrane Proteins / metabolism Mice Non-alcoholic Fatty Liver Disease / metabolism Rats
Fatty Liver Liver Perfusion Triglycerides VLDL

Journal

Cellular and molecular gastroenterology and hepatology
ISSN: 2352-345X
Titre abrégé: Cell Mol Gastroenterol Hepatol
Pays: United States
ID NLM: 101648302

Informations de publication

Date de publication:
2022
Historique:
received: 01 10 2021
revised: 07 12 2021
accepted: 08 12 2021
pubmed: 20 12 2021
medline: 5 4 2022
entrez: 19 12 2021
Statut: ppublish

Résumé

Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels. Tm6sf2 Two lines of Tm6sf2 Tm6sf2 TM6SF2 acts in the smooth endoplasmic reticulum to promote bulk lipidation of apolipoprotein B-containing lipoproteins, thus preventing fatty liver disease.

Sections du résumé

BACKGROUND & AIMS
Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels. Tm6sf2
METHODS
Two lines of Tm6sf2
RESULTS
Tm6sf2
CONCLUSIONS
TM6SF2 acts in the smooth endoplasmic reticulum to promote bulk lipidation of apolipoprotein B-containing lipoproteins, thus preventing fatty liver disease.

Identifiants

DOI: 10.1016/j.jcmgh.2021.12.008 PMID: 34923175 PMC: PMC8804273
pubmed: 34923175
pii: S2352-345X(21)00258-7
doi: 10.1016/j.jcmgh.2021.12.008
pmc: PMC8804273
pii:
doi:

Substances chimiques

Membrane Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

879-899

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL020948
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK078184
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK112529
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK128168
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK090066
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Fei Luo (F)

Department of Molecular Genetics, Dallas, Texas; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Eriks Smagris (E)

Department of Molecular Genetics, Dallas, Texas.

Sarah A Martin (SA)

Department of Molecular Genetics, Dallas, Texas.

Goncalo Vale (G)

Department of Molecular Genetics, Dallas, Texas; Center for Human Nutrition, Dallas, Texas.

Jeffrey G McDonald (JG)

Department of Molecular Genetics, Dallas, Texas; Center for Human Nutrition, Dallas, Texas.

Justin A Fletcher (JA)

Center for Human Nutrition, Dallas, Texas.

Shawn C Burgess (SC)

Center for Human Nutrition, Dallas, Texas.

Helen H Hobbs (HH)

Department of Molecular Genetics, Dallas, Texas; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: Helen.hobbs@utsouthwestern.edu.

Jonathan C Cohen (JC)

Center for Human Nutrition, Dallas, Texas. Electronic address: Jonathan.Cohen@utsouthwestern.edu.

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Classifications MeSH

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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Hepatic TM6SF2 Is Required for Lipidation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hepatic TM6SF2 Is Required for Lipidation of...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Hepatic TM6SF2 Is Required for Lipidation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Hepatic TM6SF2 Is Required for Lipidation of...