Incidence of lung and human papilloma virus-associated malignancies in HIV-infected patients.
Journal
AIDS (London, England)
ISSN: 1473-5571
Titre abrégé: AIDS
Pays: England
ID NLM: 8710219
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
pubmed:
20
12
2021
medline:
22
4
2022
entrez:
19
12
2021
Statut:
ppublish
Résumé
Cancers represent one of the leading cause of mortality/morbidity in patients with HIV (PWH) in industrialized countries. The objective of our study was to compare incidence of lung and human papilloma virus (HPV)-related cancers among PWH with general population over the 2010-2017 period. Prospective and multicenter cohort study. The study included patients with lung and HPV-related cancers from the ANRS CO3 Aquitaine cohort (PWH) and the general population-based cancer registry in Gironde area. We calculated incidence rates for 100 000 person-years and incidence rate ratios (IRR). Among the 3572 PWH, 70 cancers were diagnosed in 68 patients including 35 lung and 35 HPV-related cancers (18 oropharyngeal, 11 anal, 6 cervix). Incidence rates of lung and HPV-related-cancers were 311.1 in PWH and 209.8 in general population for 100 000 person-years, respectively. IRR were significantly increased in PWH for lung 1.8 [1.4-2.2] and HPV-related cancer 1.3 [1.0-1.6] and particularly high for patients between 40 and 49 years old [IRR 4.4 (2.3-8.4) for lung cancer and 3.7 (2.1-6.5) for HPV-related cancer]. We emphasized the persistent high risk of lung and HPV-related cancer despite advent of antiretroviral therapies, particularly in the age strata of 40-49 years. Screening procedures should take into account this finding.
Identifiants
pubmed: 34923517
doi: 10.1097/QAD.0000000000003152
pii: 00002030-202204010-00007
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
665-673Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Références
Morlat P, Roussillon C, Henard S, Salmon D, Bonnet F, Cacoub P, et al. ANRS EN20 Mortalité 2010 Study Group. Causes of death among HIV-infected patients in France in 2010 (national survey): trends since 2000 . AIDS 2014; 28:1181–1191.
Vandenhende M-A, Roussillon C, Henard S, Morlat P, Oksenhendler E, Aumaitre H, et al. Cancer-related causes of death among HIV-infected patients in France in 2010: evolution since 2000 . PLoS One 2015; 10:e0129550.
Chen Y-C, Li C-Y, Liu H-Y, Lee N-Y, Ko W-C, Ko N-Y. Effect of antiretroviral therapy on the incidence of cervical neoplasia among HIV-infected women: a population-based cohort study in Taiwan . AIDS 2014; 28:709–715.
Kelly H, Weiss HA, Benavente Y, de Sanjose S, Mayaud P. ART and HPV Review Group. Association of antiretroviral therapy with high-risk human papillomavirus, cervical intraepithelial neoplasia, and invasive cervical cancer in women living with HIV: a systematic review and meta-analysis . Lancet HIV 2018; 5:e45–e58.
Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Holmberg SD, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators . N Engl J Med 1998; 8:853–860.
Chaturvedi AK, Pfeiffer RM, Chang L, Goedert JJ, Biggar RJ, Engels EA. Elevated risk of lung cancer among people with AIDS . AIDS 2007; 21:207–213.
Kirk GD, Merlo C, O’Driscoll P, Mehta S, Galai N, Vlahov D, et al. HIV infection is associated with an increased risk for lung cancer, independent of smoking . Clin Infect Dis 2007; 45:103–110.
Coghill AE, Han X, Suneja G, Lin CC, Jemal A, Shiels MS. Advanced stage at diagnosis and elevated mortality among US patients with cancer infected with HIV in the National Cancer Data Base . Cancer 2019; 125:2868–2876.
Shiels MS, Althoff KN, Pfeiffer RM, Achenbach C, Abraham A, Castilho J, et al. North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiologic Databases to Evaluate AIDS (IeDEA). HIV infection, immunosuppression, and age at diagnosis of non-AIDS-defining cancers . Clin Infect Dis 2017; 64:468–475.
Rubinstein PG, Aboulafia DM, Zloza A. Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges . AIDS 2014; 28:453–465.
Shiels MS, Pfeiffer RM, Gail MH, Hall HI, Li J, Chaturvedi AK, et al. Cancer burden in the HIV-infected population in the United States . JNCI 2011; 103:753–762.
Guiguet M, Boué F, Cadranel J, Lang JM, Rosenthal E, Costagliola D. Clinical Epidemiology Group of the FHDH-ANRS CO4 cohort. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study . Lancet Oncol 2009; 10:1152–1159.
Hleyhel M, Hleyhel M, Bouvier AM, Belot A, Tattevin P, Pacanowski J, et al. Cancer Risk Group of the French Hospital Database on HIV (FHDH-ANRS CO4). Risk of non-AIDS-defining cancers among HIV-1-infected individuals in France between 1997 and 2009: results from a French cohort . AIDS 2014; 28:2109–2118.
Clifford GM, Polesel J, Rickenbach M, Dal Maso L, Keiser O, Kofler A, et al. Swiss HIV Cohort. Cancer Risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy . JNCI 2005; 97:425–432.
Abraham AG, D'Souza G, Jing Y, Gange SJ, Sterling TR, Silverberg MJ, et al. North American AIDS Cohort Collaboration on Research and Design of IeDEA. Invasive cervical cancer risk among HIV-infected women: a North American Multicohort Collaboration Prospective Study . JAIDS 2013; 62:405–413.
Younas M, Psomas C, Reynes J, Corbeau P. Immune activation in the course of HIV-1 infection: causes, phenotypes and persistence under therapy . HIV Medicine 2016; 17:89–105.
Robbins HA, Shiels MS, Pfeiffer RM, Engels EA. Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States . AIDS 2014; 28:881–890.
Hernández-Ramírez RU, Shiels MS, Dubrow R, Engels EA. Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study . Lancet HIV 2017; 4:e495–e504.
Zhu W, Mao Y, Tang H, McGoogan JM, Zhang ZF, Detels R, et al. Spectrum of malignancies among the population of adults living with HIV infection in China: a nationwide follow-up study, 2008–2011 . PLoS One 2019; 14:e0219766.
Stapelfeld C, Dammann C, Maser E. Sex-specificity in lung cancer risk . Int J Cancer 2020; 146:2376–2382.
Shebl FM, Engels EA, Goedert JJ, Chaturvedi AK. Pulmonary infections and risk of lung cancer among persons with AIDS . JAIDS 2010; 55:375–379.
Belot A, Grosclaude P, Bossard N, Jougal E, Benhamou E, Delafosse P, et al. Cancer incidence and mortality in France over the period 1980–2005 . Rev D’Épidémiologie Santé Publique 2008; 56:159–175.
Chaturvedi AK, Madeleine MM, Biggar RJ, Engels EA. Risk of human papillomavirus-associated cancers among persons with AIDS . JNCI 2009; 101:1120–1130.
Grabar S, Hleyhel M, Belot A, Bouvier AM, Tattevin P, Pacanowski J, et al. Invasive cervical cancer in HIV -infected women: risk and survival relative to those of the general population in France. Results from the French Hospital Database on HIV (FHDH)–Agence Nationale de Recherches sur le SIDA et les Hépatites Virales (ANRS) CO 4 cohort study . HIV Med 2019; 20:222–229.
Clifford GM, Franceschi S, Keiser O, Schöni-Affolter F, Lise M, Dehler S, et al. Immunodeficiency and the risk of cervical intraepithelial neoplasia 2/3 and cervical cancer: a nested case-control study in the Swiss HIV cohort study: cervical cancer and neoplasia in SHCS . Int J Cancer 2016; 138:1732–1740.
Shiels MS, Pfeiffer RM, Chaturvedi AK, Kreimer AR, Engels EA. Impact of the HIV epidemic on the incidence rates of anal cancer in the United States . JNCI 2012; 104:1591–1598.
Silverberg MJ, Lau B, Justice AC, Engels E, Gill MJ, Goedert JJ, et al. North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA. Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America . Clin Infect Dis 2012; 54:1026–1034.
Piketty C, Cochand-Priollet B, Lanoy E, Si-Mohamed A, Trabelsi S, Tubiana R, et al. Valparaiso Study Group. Lack of regression of anal squamous intraepithelial lesions despite immune restoration under cART . AIDS 2013; 27:401–406.
Wang CJ, Sparano J, Palefsky JM. Human immunodeficiency virus/AIDS, human papillomavirus, and anal cancer . Surg Oncol Clin N Am 2017; 26:17–31.
Piketty C, Selinger-Leneman H, Bouvier A-M, Belot A, Mary-Krause M, Duvivier C, et al. Incidence of HIV-related anal cancer remains increased despite long-term combined antiretroviral treatment: results from the French Hospital Database on HIV . J Clin Oncol 2012; 30:4360–4366.
Picard A, Arowas L, Piroth L, Heard I, Ferry T. ORL-HIV-HPV study group. Head and neck squamous cell carcinoma in people living with HIV in France . Médecine Mal Infect 2018; 48:503–508.
Patel P, Hanson D, Sullivan PS, Novak RM, Moorman AC, Tong TC, et al. Adult and Adolescent Spectrum of Disease Project and HIV Outpatient Study Investigators. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003 . Ann Intern Med 2008; 148:728–736.
Beachler DC, Abraham AG, Silverberg MJ, Jing Y, Fakhry C, Gill MJ, et al. North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA. Incidence and risk factors of HPV-related and HPV-unrelated Head and Neck Squamous Cell Carcinoma in HIV-infected individuals . Oral Oncol 2014; 50:1169–1176.
Silverberg MJ, Lau B, Achenbach CJ, Jing Y, Althoff KN, D'Souza G, et al. North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS. Cumulative incidence of cancer among persons with HIV in North America: a cohort study . Ann Intern Med 2015; 163:507.
Chew EY, Hartman CM, Richardson PA, Zevallos JP, Sikora AG, Kramer JR, Chiao EY. Risk factors for oropharynx cancer in a cohort of HIV-infected veterans . Oral Oncol 2017; 68:60–66.
Trickey A, May MT, Gill MJ, Grabar S, Vehreschild J, Wit F, et al. Cause-specific mortality after diagnosis of cancer among HIV-positive patients: a collaborative analysis of cohort studies . Int J Cancer 2020; 146:3134–3146.
EACS Guidelines version 11.0, October 2021.