Amino acid transporters as modulators of glucose homeostasis.
GCN2
adipocytes
gluconeogenesis
solute carrier
β-cell
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
22
08
2021
revised:
01
11
2021
accepted:
18
11
2021
pubmed:
21
12
2021
medline:
28
4
2022
entrez:
20
12
2021
Statut:
ppublish
Résumé
Amino acids modulate glucose homeostasis. Cytosolic levels of amino acids are regulated by amino acid transporters, modulating insulin release, protein synthesis, cell proliferation, cell fate, and metabolism. In β-cells, amino acid transporters modulate incretin-stimulated insulin release. In the liver, amino acid transporters provide glutamine and alanine for gluconeogenesis. Intestinal amino acid transporters facilitate the intake of amino acids causing protein restriction when inactive. Adipocyte development is regulated by amino acid transporters through activation of mechanistic target of rapamycin (mTORC1) and amino acid-related metabolites. The accumulation and metabolism of branched-chain amino acids (BCAAs) in muscle depends on transporters. The integration between amino acid metabolism and transport is critical for the maintenance and function of tissues and cells involved in glucose homeostasis.
Identifiants
pubmed: 34924221
pii: S1043-2760(21)00267-8
doi: 10.1016/j.tem.2021.11.004
pii:
doi:
Substances chimiques
Amino Acid Transport Systems
0
Amino Acids
0
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120-135Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.