Nicotinic receptors as SARS-CoV-2 spike co-receptors?

COVID-19 Humans Receptors, Nicotinic Receptors, Virus SARS-CoV-2 Spike Glycoprotein, Coronavirus
ACE-2, Angiotensin converting enzyme-2 BR, Binding region COVID-19 COVID-19, Coronavirus disease 2019 ETD, Extracellular topological domain Lung Nicotinic receptors PDB, Protein data bank RBD, Receptor binding domain SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 hACE2 nAChRs, Nicotinic acetylcholine receptors vdw, Van der Waals

Journal

Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 10 02 2021
revised: 16 11 2021
accepted: 10 12 2021
entrez: 20 12 2021
pubmed: 21 12 2021
medline: 24 12 2021
Statut: ppublish

Résumé

Nicotinic acetylcholine receptors (nAChRs) play an important role in homeostasis and respiratory diseases. Controversies regarding the association between COVID-19 hospitalizations and smoking suggest that nAChRs may contribute to SARS-CoV-2 respiratory syndrome. We recently detailed the expression and localization of all nAChR subunits in the human lung. Since virus association with nAChRs has been shown in the past, we hypothesize that nAChR subunits act as SARS-CoV-2 Spike co-receptors. Based on sequence alignment analysis, we report domains of high molecular similarities in nAChRs with the binding domain of hACE2 for SARS-CoV-2 Spike protein. This hypothesis supported by

Identifiants

DOI: 10.1016/j.mehy.2021.110741 PMID: 34924680 PMC: PMC8669939
pubmed: 34924680
doi: 10.1016/j.mehy.2021.110741
pii: S0306-9877(21)00260-7
pmc: PMC8669939
doi:

Substances chimiques

Receptors, Nicotinic 0
Receptors, Virus 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article

Langues

eng

Pagination

110741

Informations de copyright

© 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Valérian Dormoy (V)

University of Reims Champagne-Ardenne, Inserm, P3Cell UMR-S1250, SFR CAP-SANTE, 51092 Reims, France.

Jeanne-Marie Perotin (JM)

University of Reims Champagne-Ardenne, Inserm, P3Cell UMR-S1250, SFR CAP-SANTE, 51092 Reims, France.
CHU of Reims, Hôpital Maison Blanche, Department of Respiratory Diseases, 51092 Reims, France.

Philippe Gosset (P)

University of Lille, CNRS UMR8204, Inserm U1019, CHRU Lille, Institut Pasteur Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.

Uwe Maskos (U)

Institut Pasteur Paris, Université de Paris, Integrative Neurobiology of Cholinergic Systems, CNRS, UMR 3571, Paris, France.

Myriam Polette (M)

University of Reims Champagne-Ardenne, Inserm, P3Cell UMR-S1250, SFR CAP-SANTE, 51092 Reims, France.
CHU Reims, Hôpital Maison Blanche, Department of Biopathology, 51092 Reims, France.

Gaëtan Deslée (G)

University of Reims Champagne-Ardenne, Inserm, P3Cell UMR-S1250, SFR CAP-SANTE, 51092 Reims, France.
CHU of Reims, Hôpital Maison Blanche, Department of Respiratory Diseases, 51092 Reims, France.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Nicotinic receptors as SARS-CoV-2 spike co-receptors?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nicotinic receptors as SARS-CoV-2 spike co-receptors?
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Nicotinic receptors as SARS-CoV-2 spike co-receptors?
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Nicotinic receptors as SARS-CoV-2 spike co-receptors?
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Nicotinic receptors as SARS-CoV-2 spike co-receptors?
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › Nicotinic receptors as SARS-CoV-2 spike co-receptors?