Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review.
BDNF
antidepressant
depression
glutamate
ketamine
monoamines
neurogenesis
treatment-resistant depression
Journal
Frontiers in behavioral neuroscience
ISSN: 1662-5153
Titre abrégé: Front Behav Neurosci
Pays: Switzerland
ID NLM: 101477952
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
08
2021
accepted:
28
10
2021
entrez:
20
12
2021
pubmed:
21
12
2021
medline:
21
12
2021
Statut:
epublish
Résumé
The serendipitous discovery of ketamine's antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years. Ketamine provides an exciting challenge to traditional concepts of antidepressant drug therapy, producing rapid antidepressant effects seemingly without targeting monoaminergic pathways in the conventional way. In consequence, the advent of ketamine has spawned a plethora of neurobiological research into its putative mechanisms. Here, we provide a brief overview of current theories of antidepressant drug action including monoaminergic signaling, disinhibition of glutamatergic neurotransmission, neurotrophic and neuroplastic effects, and how these might relate to ketamine. Given that research into ketamine has not yet yielded new therapies beyond ketamine itself, current knowledge gaps and limitations of available studies are also discussed.
Identifiants
pubmed: 34924969
doi: 10.3389/fnbeh.2021.759466
pmc: PMC8681015
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
759466Informations de copyright
Copyright © 2021 Colla, Scheerer, Weidt, Seifritz and Kronenberg.
Déclaration de conflit d'intérêts
The authors are conducting a study of oral ketamine in TRD funded by Ketabon GmbH. ES serves on advisory boards of Janssen.
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