Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation.
C-reactive protein
biomarkers
immunosenescence
inflammaging
inflammation
inflammation mediators - blood
interleukin-6
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
09
2021
accepted:
09
11
2021
entrez:
20
12
2021
pubmed:
21
12
2021
medline:
15
2
2022
Statut:
epublish
Résumé
Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation that plays a major role in immunosenescence and in development and progression of many diseases. But currently, there are no recognized standard biomarkers to assess SCI levels alone, and SCI is typically measured by combining biomarkers of acute inflammation and infection, e.g., CRP, IL-6, and TNFα. In this review, we highlight 10 properties and characteristics that are shared by the blood protein
Identifiants
pubmed: 34925360
doi: 10.3389/fimmu.2021.780641
pmc: PMC8674945
doi:
Substances chimiques
Biomarkers
0
Receptors, Urokinase Plasminogen Activator
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
780641Subventions
Organisme : Medical Research Council
ID : MR/P005918/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1002190
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Rasmussen, Petersen and Eugen-Olsen.
Déclaration de conflit d'intérêts
JE-O is a named inventor on patents on suPAR as a prognostic biomarker. The patents are owned by Copenhagen University Hospital Amager and Hvidovre, Denmark, and is licensed to ViroGates A/S. JE-O is a co-founder, shareholder, and CSO of ViroGates A/S. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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