Exacerbation of Secondary Cold Agglutinin Syndrome in the Setting of SARS-CoV-2.
autoimmune hemolytic anemia (aiha)
cold agglutinin syndrome
covid coagulopathy
covid hypercoagulability
covid-19
covid-19 associated coagulopathy
covid-19 pneumonia
sars-cov-2
severe acute respiratory syndrome coronavirus-2 (sars-cov-2)
transfusion in covid 19 pandemic
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
accepted:
09
11
2021
entrez:
20
12
2021
pubmed:
21
12
2021
medline:
21
12
2021
Statut:
epublish
Résumé
In this report, we present a case of exacerbation of cold agglutinin syndrome (CAS) potentially due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. An 83-year-old female with a history of cold agglutinin hemolytic anemia presented with shortness of breath, productive cough, worsening orthopnea, darkening fingers and urine, and jaundice. Laboratory investigations found elevated white blood cells (WBC) and total bilirubin, severely low hemoglobin, and positive direct Coombs test. Moreover, SARS-CoV-2 RNA was also found to be positive in a sample from the nasal swab by reverse transcription-polymerase chain reaction (RT-PCR), indicating exacerbation of CAS secondary to viral coronavirus 2019 (COVID-19) infection. A treatment regime for SARS-CoV-2 consisting of five days of remdesivir and seven days of dexamethasone 6 mg IV was initiated, resulting in significant improvement in the patient's condition.
Identifiants
pubmed: 34925989
doi: 10.7759/cureus.19387
pmc: PMC8655486
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e19387Informations de copyright
Copyright © 2021, Bhagat et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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