VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth
Hec1
Ndc80
cell division
mitosis
spindle assembly checkpoint
Journal
Oncoscience
ISSN: 2331-4737
Titre abrégé: Oncoscience
Pays: United States
ID NLM: 101636666
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
07
2021
accepted:
01
12
2021
entrez:
20
12
2021
pubmed:
21
12
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Hec1 (Highly expressed in cancer 1) resides in the outer kinetochore where it works to facilitate proper kinetochore-microtubule interactions during mitosis. Hec1 is overexpressed in various cancers and its expression shows correlation with high tumour grade and poor patient prognosis. Chemical perturbation of Hec1 is anticipated to impair kinetochore-microtubule binding, activate the spindle assembly checkpoint (spindle checkpoint) and thereby suppress cell proliferation. In this study, we performed high-throughput screen to identify novel small molecules that target the Hec1 calponin homology domain (CHD), which is needed for normal microtubule attachments. 4 million compounds were first virtually fitted against the CHD, and the best hit molecules were evaluated
Identifiants
pubmed: 34926718
doi: 10.18632/oncoscience.549
pii: 549
pmc: PMC8667816
doi:
Types de publication
Journal Article
Langues
eng
Pagination
134-153Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM079373
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM040506
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM130293
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM126980
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM134842
Pays : United States
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors have no conflicts of interest to declare.
Références
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16113-8
pubmed: 22908300
Mol Pharmacol. 1995 Jun;47(6):1197-203
pubmed: 7603460
J Cell Sci. 2004 Apr 1;117(Pt 9):1757-71
pubmed: 15075237
Curr Biol. 2011 Jul 12;21(13):1158-65
pubmed: 21723127
J Cell Biol. 2014 Jul 7;206(1):45-59
pubmed: 24982430
Cell. 2008 May 2;133(3):427-39
pubmed: 18455984
J Cell Sci. 2003 Aug 15;116(Pt 16):3347-62
pubmed: 12829748
EMBO J. 2009 Apr 22;28(8):1099-110
pubmed: 19300438
PLoS One. 2014 May 08;9(5):e96426
pubmed: 24810913
Curr Biol. 2004 Jan 20;14(2):131-7
pubmed: 14738735
J Cell Biol. 2002 Nov 25;159(4):549-55
pubmed: 12438418
Curr Biol. 2003 Dec 2;13(23):2103-9
pubmed: 14654001
Mol Cancer. 2011 Feb 27;10:23
pubmed: 21352579
Mol Biol Cell. 2011 Apr 15;22(8):1217-26
pubmed: 21325630
Blood. 2014 Aug 14;124(7):1038-46
pubmed: 24920586
Gene Ther. 2007 May;14(10):814-27
pubmed: 17330085
Acta Pharmacol Sin. 2013 Apr;34(4):541-8
pubmed: 23474708
Science. 2006 Jan 20;311(5759):388-91
pubmed: 16424343
Cell. 2011 Aug 19;146(4):555-67
pubmed: 21854981
Cancer Chemother Pharmacol. 2012 Mar;69(3):733-41
pubmed: 22020315
Mol Biol Cell. 2011 Mar 15;22(6):759-68
pubmed: 21270439
Br J Haematol. 2013 Oct;163(2):214-22
pubmed: 24033250
J Med Chem. 2009 Mar 26;52(6):1757-67
pubmed: 19243176
Mol Endocrinol. 1996 Jun;10(6):607-12
pubmed: 8776720
Curr Biol. 2008 Nov 25;18(22):1778-84
pubmed: 19026543
Nature. 1999 Dec 16;402(6763):778-84
pubmed: 10617199
Invest New Drugs. 2013 Aug;31(4):1001-7
pubmed: 23329066
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16719-24
pubmed: 18940925
Cell. 2006 Dec 1;127(5):983-97
pubmed: 17129783
J Chem Inf Model. 2011 Mar 28;51(3):578-96
pubmed: 21323318
J Cell Biol. 2003 Apr 28;161(2):267-80
pubmed: 12719470
Curr Biol. 1998 Mar 26;8(7):377-85
pubmed: 9545195
Carcinogenesis. 2009 Jun;30(6):1032-40
pubmed: 19395653
Cell. 2009 Mar 6;136(5):865-75
pubmed: 19269365
J Exp Clin Cancer Res. 2014 Jan 09;33:6
pubmed: 24401611
FEBS Lett. 2007 Jun 19;581(15):2862-9
pubmed: 17521635
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4492-7
pubmed: 11274370
Genes Dev. 2003 Jan 1;17(1):101-14
pubmed: 12514103
Clin Lymphoma Myeloma Leuk. 2014 Jun;14(3):223-30
pubmed: 24355079
Methods Cell Biol. 2010;95:641-56
pubmed: 20466157
J Biol Chem. 2004 Mar 26;279(13):12997-3003
pubmed: 14722118
Nat Rev Drug Discov. 2010 Oct;9(10):790-803
pubmed: 20885410
Blood. 2014 Aug 7;124(6):899-906
pubmed: 24963043
J Cell Biol. 2010 Jul 12;190(1):25-34
pubmed: 20624899
J Cell Sci. 2011 Feb 15;124(Pt 4):622-34
pubmed: 21266467
J Biotechnol. 1994 Aug 15;36(2):95-119
pubmed: 7765237
Leukemia. 2015 Jan;29(1):11-9
pubmed: 25027517
Chromosoma. 2008 Apr;117(2):169-79
pubmed: 18057949
Gene Ther. 2006 Jan;13(1):1-7
pubmed: 16121206
Blood Cancer J. 2014 Aug 15;4:e238
pubmed: 25127392
Curr Biol. 2011 Feb 8;21(3):207-13
pubmed: 21256019
Cancer Res. 2008 Oct 15;68(20):8393-9
pubmed: 18922912
Mol Biol Cell. 2011 Oct;22(19):3584-94
pubmed: 21832156
PLoS One. 2010 May 03;5(5):e10431
pubmed: 20454659
Curr Biol. 2008 Nov 25;18(22):1785-91
pubmed: 19026542
Cell. 2006 Dec 1;127(5):969-82
pubmed: 17129782
Nat Struct Mol Biol. 2007 Jan;14(1):54-9
pubmed: 17195848
Oncogene. 2018 Jan 11;37(2):231-240
pubmed: 28925395
Dev Cell. 2004 Jul;7(1):45-60
pubmed: 15239953
J Cell Biol. 2003 Apr 28;161(2):281-94
pubmed: 12707311
J Cell Biol. 2010 May 17;189(4):713-23
pubmed: 20479468
J Cell Biol. 2002 May 13;157(4):551-6
pubmed: 12011106
J Biol Chem. 2002 Dec 20;277(51):49408-16
pubmed: 12386167
Mol Biol Cell. 2005 Feb;16(2):519-31
pubmed: 15548592
Nat Rev Mol Cell Biol. 2007 May;8(5):379-93
pubmed: 17426725