Voriconazole-Cyclodextrin Supramolecular Ternary Complex-Loaded Ocular Films for Management of Fungal Keratitis.
antifungal
cyclodextrins
inclusion complex
ocular delivery
ocular films
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
03 01 2022
03 01 2022
Historique:
pubmed:
21
12
2021
medline:
29
3
2022
entrez:
20
12
2021
Statut:
ppublish
Résumé
Fungal keratitis is one of the leading causes of ophthalmic mycosis affecting the vision due to corneal scarring. Voriconazole (VRC) is the most preferred azole antifungal agent for treating ocular mycotic infections. Ocular drug delivery is challenging due to the shorter corneal residence time of the formulation requiring frequent administration, leading to poor patient compliance. The present study aimed at improving the solubility, transcorneal permeation, and efficacy of voriconazole
Identifiants
pubmed: 34928610
doi: 10.1021/acs.molpharmaceut.1c00746
doi:
Substances chimiques
Antifungal Agents
0
Cyclodextrins
0
Voriconazole
JFU09I87TR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM