Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick.
ETP-ALL biology
Lymphoid-myeloid potential
Molecular pathogenesis.
Journal
Biomarker research
ISSN: 2050-7771
Titre abrégé: Biomark Res
Pays: England
ID NLM: 101607860
Informations de publication
Date de publication:
20 Dec 2021
20 Dec 2021
Historique:
received:
29
09
2021
accepted:
23
11
2021
entrez:
21
12
2021
pubmed:
22
12
2021
medline:
22
12
2021
Statut:
epublish
Résumé
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.
Identifiants
pubmed: 34930475
doi: 10.1186/s40364-021-00347-z
pii: 10.1186/s40364-021-00347-z
pmc: PMC8686563
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
89Informations de copyright
© 2021. The Author(s).
Références
Eur J Haematol. 2014 Mar;92(3):211-8
pubmed: 24329989
Blood. 2013 Sep 19;122(12):2093-103
pubmed: 23926305
Br J Haematol. 2014 Aug;166(3):421-4
pubmed: 24708207
J Biomed Sci. 2020 Jul 21;27(1):81
pubmed: 32690020
PLoS One. 2013;8(1):e53190
pubmed: 23359050
Nature. 2008 Apr 10;452(7188):768-72
pubmed: 18401412
J Exp Med. 2011 Dec 19;208(13):2571-9
pubmed: 22162831
Br J Haematol. 2019 Aug;186(4):538-548
pubmed: 31115909
Immunity. 2007 Jun;26(6):678-89
pubmed: 17582341
Nature. 2012 Jan 11;481(7380):157-63
pubmed: 22237106
Blood. 2015 Mar 12;125(11):1759-67
pubmed: 25645356
Cancer Cell. 2018 Feb 12;33(2):274-291.e8
pubmed: 29438697
Onco Targets Ther. 2021 Jun 18;14:3795-3802
pubmed: 34168464
Am J Hematol. 2021 May 1;96(5):589-598
pubmed: 33639000
Blood. 2013 Jun 6;121(23):4749-52
pubmed: 23603912
Haematologica. 2014 Jan;99(1):94-102
pubmed: 23975177
Nature. 2008 Apr 10;452(7188):764-7
pubmed: 18401411
Leuk Res. 2013 Sep;37(9):1027-34
pubmed: 23827350
Leukemia. 2020 Aug;34(8):2198-2205
pubmed: 32457355
J Exp Med. 2014 Apr 7;211(4):701-13
pubmed: 24687960
J Immunol. 2010 Jul 1;185(1):284-93
pubmed: 20543111
Blood Cancer J. 2012 Jan;2(1):e55
pubmed: 22829239
J Exp Med. 2005 Jul 4;202(1):21-31
pubmed: 15983065
J Hematol Oncol. 2016 Sep 22;9(1):95
pubmed: 27658391
Cell Rep. 2016 Mar 1;14(8):1953-65
pubmed: 26904942
Nat Genet. 2017 Aug;49(8):1211-1218
pubmed: 28671688
Ther Adv Hematol. 2020 Jul 16;11:2040620720929475
pubmed: 32733662
Lancet Oncol. 2009 Feb;10(2):147-56
pubmed: 19147408
Blood. 2005 Mar 1;105(5):1930-6
pubmed: 15522952
J Clin Invest. 2021 Jun 24;:
pubmed: 34166225
Br J Haematol. 2012 Feb;156(3):358-65
pubmed: 22128890
Nat Genet. 2020 Apr;52(4):388-400
pubmed: 32203470
Blood. 2021 Sep 2;138(9):773-784
pubmed: 33876209
Leuk Res. 2019 Mar;78:3-11
pubmed: 30641417
Cancer Cell. 2002 Feb;1(1):75-87
pubmed: 12086890
Immunity. 2004 Jun;20(6):735-45
pubmed: 15189738
Blood. 2005 Jul 1;106(1):274-86
pubmed: 15774621
Blood. 2014 Dec 11;124(25):3738-47
pubmed: 25301704
Nat Commun. 2015 Jan 07;6:5794
pubmed: 25565005
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
Int J Mol Sci. 2021 Apr 26;22(9):
pubmed: 33925883
Blood. 2017 Jan 26;129(4):424-447
pubmed: 27895058
Blood. 2016 Apr 14;127(15):1863-9
pubmed: 26747249
Cancer Discov. 2014 Sep;4(9):1074-87
pubmed: 24994123
Medicine (Baltimore). 2018 Oct;97(41):e12743
pubmed: 30313079
Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000539
pubmed: 27148573
Nat Immunol. 2012 Feb 19;13(4):412-9
pubmed: 22344248
Cancer Cell. 2011 Apr 12;19(4):484-97
pubmed: 21481790
Blood. 2011 Oct 27;118(17):4646-56
pubmed: 21828136
Int J Lab Hematol. 2019 Apr;41(2):e32-e37
pubmed: 30407727
Nat Commun. 2021 Jun 17;12(1):3708
pubmed: 34140506