INTERSTAARS: Attention training for infants with elevated likelihood of developing ADHD: A proof-of-concept randomised controlled trial.

Attention Attention Deficit Disorder with Hyperactivity / therapy Child Humans Infant Treatment Outcome

Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
20 12 2021
Historique:
received: 27 08 2020
accepted: 13 10 2021
revised: 02 07 2021
entrez: 21 12 2021
pubmed: 22 12 2021
medline: 1 2 2022
Statut: epublish

Résumé

Attention-deficit/hyperactivity disorder (ADHD) is first diagnosed during middle childhood, when patterns of difficulty are often established. Pre-emptive approaches that strengthen developing cognitive systems could offer an alternative to post-diagnostic interventions. This proof-of-concept randomised controlled trial (RCT) tested whether computerised gaze-based attention training is feasible and improves attention in infants liable to develop ADHD. Forty-three 9- to 16-month-old infants with a first-degree relative with ADHD were recruited (11/2015-11/2018) at two UK sites and randomised with minimisation by site and sex to receive 9 weekly sessions of either (a) gaze-contingent attention training (intervention; n = 20); or (b) infant-friendly passive viewing of videos (control, n = 23). Sessions were delivered at home with blinded outcome assessments. The primary outcome was a composite of attention measures jointly analysed via a multivariate ANCOVA with a combined effect size (ES) from coefficients at baseline, midpoint and endpoint (Registration: ISRCTN37683928 ). Uptake and compliance was good but intention-to-treat analysis showed no significant differences between 20 intervention and 23 control infants on primary (ES -0.4, 95% CI -0.9 to 0.2; Complier-Average-Causal Effect ES -0.6, 95% CI -1.6 to 0.5) or secondary outcomes (behavioural attention). There were no adverse effects on sleep but a small increase in post-intervention session fussiness. Although feasible, there was no support for short-term effects of gaze-based attention training on attention skills in early ADHD. Longer-term outcomes remain to be assessed. The study highlights challenges and opportunities for pre-emptive intervention approaches to the management of ADHD.

Identifiants

DOI: 10.1038/s41398-021-01698-9 PMID: 34930893 PMC: PMC8688472
pubmed: 34930893
doi: 10.1038/s41398-021-01698-9
pii: 10.1038/s41398-021-01698-9
pmc: PMC8688472
doi:

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

644

Subventions

Organisme : Medical Research Council
ID : MR/T003057/1
Pays : United Kingdom
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/K021389/1

Informations de copyright

© 2021. The Author(s).

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Auteurs

Amy Goodwin (A)

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. amy.l.goodwin@kcl.ac.uk.
ORCID: 0000-0003-2585-8452

Emily J H Jones (EJH)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK. e.jones@bbk.ac.uk.
ORCID: 0000-0001-5747-9540

Simona Salomone (S)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.
Centre for Oral Clinical Research (COCR) & Centre for Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, London, UK.

Luke Mason (L)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.

Rebecca Holman (R)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.

Jannath Begum-Ali (J)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.

Anna Hunt (A)

Department of Psychology, University of Southampton, Southampton, UK.
ORCID: 0000-0002-0864-4113

Martin Ruddock (M)

Department of Psychology, University of Southampton, Southampton, UK.

George Vamvakas (G)

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Emily Robinson (E)

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Catherine J Holden (CJ)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.

Chloë Taylor (C)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.

Tim J Smith (TJ)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.

Edmund Sonuga-Barke (E)

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Department of Psychology, University of Southampton, Southampton, UK.

Patrick Bolton (P)

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Tony Charman (T)

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
ORCID: 0000-0003-1993-6549

Andrew Pickles (A)

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Sam Wass (S)

Department of Psychology, University of East London, London, UK.
ORCID: 0000-0002-7421-3493

Mark H Johnson (MH)

Centre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK. mark.johnson@bbk.ac.uk.
Department of Psychology, University of Cambridge, Cambridge, UK. mark.johnson@bbk.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Phénomènes psychologiques › Attention › INTERSTAARS: Attention training for infants...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › INTERSTAARS: Attention training for infants...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › INTERSTAARS: Attention training for infants...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › INTERSTAARS: Attention training for infants...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › INTERSTAARS: Attention training for infants...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › INTERSTAARS: Attention training for infants...