Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 12 2021
20 12 2021
Historique:
received:
12
10
2021
accepted:
03
12
2021
entrez:
21
12
2021
pubmed:
22
12
2021
medline:
26
2
2022
Statut:
epublish
Résumé
Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.
Identifiants
pubmed: 34930926
doi: 10.1038/s41598-021-03555-7
pii: 10.1038/s41598-021-03555-7
pmc: PMC8688461
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24250Subventions
Organisme : NINDS NIH HHS
ID : UH2 NS095495
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS113637
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00003/3
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS092882
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS095495
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS073557
Pays : United States
Informations de copyright
© 2021. The Author(s).
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