Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters.
Adult
Aged
Aged, 80 and over
Body Mass Index
Brain
/ diagnostic imaging
Brain Mapping
Cluster Analysis
Cross-Sectional Studies
Female
Frontal Lobe
Genetic Predisposition to Disease
Germany
/ epidemiology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Models, Genetic
Neuroimaging
Neuronal Plasticity
Polymorphism, Single Nucleotide
Prefrontal Cortex
/ physiopathology
Risk
Risk Factors
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 12 2021
20 12 2021
Historique:
received:
29
06
2021
accepted:
17
11
2021
entrez:
21
12
2021
pubmed:
22
12
2021
medline:
26
2
2022
Statut:
epublish
Résumé
Evidence from previous studies suggests that elevated body mass index (BMI) and genetic risk for obesity is associated with reduced brain volume, particularly in areas of reward-related cognition, e.g. the medial prefrontal cortex (AC-MPFC), the orbitofrontal cortex (OFC), the striatum and the thalamus. However, only few studies examined the interplay between these factors in a joint approach. Moreover, previous findings are based on cross-sectional data. We investigated the longitudinal relationship between increased BMI, brain structural magnetic resonance imaging (MRI) parameters and genetic risk scores in a cohort of n = 502 community-dwelling participants from the Study of Health in Pomerania (SHIP) with a mean follow-up-time of 4.9 years. We found that (1) increased BMI values at baseline were associated with decreased brain parameters at follow-up. These effects were particularly pronounced for the OFC and AC-MPFC. (2) The genetic predisposition for BMI had no effect on brain parameters at baseline or follow-up. (3) The interaction between the genetic score for BMI and brain parameters had no effect on BMI at baseline. Finding a significant impact of overweight, but not genetic predisposition for obesity on altered brain structure suggests that metabolic mechanisms may underlie the relationship between obesity and altered brain structure.
Identifiants
pubmed: 34930940
doi: 10.1038/s41598-021-03343-3
pii: 10.1038/s41598-021-03343-3
pmc: PMC8688483
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24246Informations de copyright
© 2021. The Author(s).
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