Receptor architecture of macaque and human early visual areas: not equal, but comparable.
Brain mapping
Comparative analysis
Cytoarchitecture
Homology
Visual processing
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
14
05
2021
accepted:
28
11
2021
pubmed:
22
12
2021
medline:
30
4
2022
entrez:
21
12
2021
Statut:
ppublish
Résumé
Existing cytoarchitectonic maps of the human and macaque posterior occipital cortex differ in the number of areas they display, thus hampering identification of homolog structures. We applied quantitative in vitro receptor autoradiography to characterize the receptor architecture of the primary visual and early extrastriate cortex in macaque and human brains, using previously published cytoarchitectonic criteria as starting point of our analysis. We identified 8 receptor architectonically distinct areas in the macaque brain (mV1d, mV1v, mV2d, mV2v, mV3d, mV3v, mV3A, mV4v), and their respective counterpart areas in the human brain (hV1d, hV1v, hV2d, hV2v, hV3d, hV3v, hV3A, hV4v). Mean densities of 14 neurotransmitter receptors were quantified in each area, and ensuing receptor fingerprints used for multivariate analyses. The 1st principal component segregated macaque and human early visual areas differ. However, the 2nd principal component showed that within each species, area-specific differences in receptor fingerprints were associated with the hierarchical processing level of each area. Subdivisions of V2 and V3 were found to cluster together in both species and were segregated from subdivisions of V1 and from V4v. Thus, comparative studies like this provide valuable architectonic insights into how differences in underlying microstructure impact evolutionary changes in functional processing of the primate brain and, at the same time, provide strong arguments for use of macaque monkey brain as a suitable animal model for translational studies.
Identifiants
pubmed: 34931262
doi: 10.1007/s00429-021-02437-y
pii: 10.1007/s00429-021-02437-y
pmc: PMC9046358
doi:
Substances chimiques
Receptors, Neurotransmitter
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1247-1263Subventions
Organisme : Horizon 2020 Framework Programme
ID : 785907
Organisme : Horizon 2020 Framework Programme
ID : 945539
Organisme : Bundesministerium für Bildung und Forschung
ID : 01GQ1902
Organisme : Helmholtz-Gemeinschaft
ID : InterLabs-0015
Informations de copyright
© 2021. The Author(s).
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