Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at

Asthma / diagnostic imaging Female Helium Humans Lung Magnetic Resonance Imaging / methods Male Mucus / diagnostic imaging Respiration Disorders Tomography, X-Ray Computed / methods

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
04 2022
Historique:
pubmed: 22 12 2021
medline: 3 5 2022
entrez: 21 12 2021
Statut: ppublish

Résumé

Background Airway mucus plugs in asthma are associated with exacerbation frequency, increased eosinophilia, and reduced lung function. The relationship between mucus plugs and spatially overlapping ventilation abnormalities observed at hyperpolarized gas MRI has not been assessed quantitatively. Purpose To assess regional associations between CT mucus plugs scored by individual bronchopulmonary segment and corresponding measurements of segmental ventilation defect percentage (VDP) at hyperpolarized helium 3 (

Identifiants

DOI: 10.1148/radiol.2021204616 PMID: 34931858 PMC: PMC8962781
pubmed: 34931858
doi: 10.1148/radiol.2021204616
pmc: PMC8962781
doi:

Substances chimiques

Helium 206GF3GB41

Types de publication

Journal Article Observational Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

184-190

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL107202
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI077439
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL109168
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL080414
Pays : United States
Organisme : NIH HHS
ID : S10 OD016394
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL080412
Pays : United States

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Auteurs

David G Mummy (DG)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0001-7885-109X

Eleanor M Dunican (EM)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).

Katherine J Carey (KJ)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).

Michael D Evans (MD)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0001-7449-3993

Brett M Elicker (BM)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0001-6188-9622

John D Newell (JD)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0002-7337-5001

David S Gierada (DS)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0002-9102-4475

Scott K Nagle (SK)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0002-0770-708X

Mark L Schiebler (ML)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0002-9120-5428

Ronald L Sorkness (RL)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).

Nizar N Jarjour (NN)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0003-0170-8927

Loren C Denlinger (LC)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).

John V Fahy (JV)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).

Sean B Fain (SB)

From the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
ORCID: 0000-0001-5461-0646

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Mucus Plugs in Asthma at CT Associated with...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Gaz rares › Hélium › Mucus Plugs in Asthma at CT Associated with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mucus Plugs in Asthma at CT Associated with...
questionsmedicales.fr › Appareil respiratoire › Poumon › Mucus Plugs in Asthma at CT Associated with...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Mucus Plugs in Asthma at CT Associated with...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Mucus › Mucus Plugs in Asthma at CT Associated with...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Mucus Plugs in Asthma at CT Associated with...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Mucus Plugs in Asthma at CT Associated with...