A J Domain Protein Functions as a Histone Chaperone to Maintain Genome Integrity and the Response to DNA Damage in a Human Fungal Pathogen.
DNA damage
J domain proteins
histone chaperone
hydroxyurea
transcriptional response
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
entrez:
22
12
2021
pubmed:
23
12
2021
medline:
23
2
2022
Statut:
ppublish
Résumé
Histone chaperoning ensures genomic integrity during routine processes such as DNA replication and transcription as well as DNA repair upon damage. Here, we identify a nuclear J domain protein, Dnj4, in the fungal pathogen Cryptococcus neoformans and demonstrate that it interacts with histones 3 and 4, suggesting a role as a histone chaperone. In support of this idea, a
Identifiants
pubmed: 34933457
doi: 10.1128/mbio.03273-21
pmc: PMC8689522
doi:
Substances chimiques
Fungal Proteins
0
Histone Chaperones
0
Histones
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0327321Subventions
Organisme : NIAID NIH HHS
ID : R01 AI053721
Pays : United States
Organisme : CIHR
ID : MOP-13234
Pays : Canada
Organisme : CIHR
ID : PJT-166043
Pays : Canada
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