Appearance of claudin-5
Blood–brain barrier
Leukocytes
Neuroinflammation
Tight junctions
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
21 Dec 2021
21 Dec 2021
Historique:
received:
08
06
2021
accepted:
23
11
2021
entrez:
22
12
2021
pubmed:
23
12
2021
medline:
29
3
2022
Statut:
epublish
Résumé
Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct intercellular solute and cellular movement. However, previous work from our laboratory found that claudin-5 (CLN-5), a TJ protein prominent at the blood-brain barrier (BBB), was also detected, ectopically, on leukocytes (CLN-5 To begin clarifying the significance of CLN-5 Flow cytometric analysis revealed CLN-5 Several leukocyte subtypes variably acquire CLN-5 in blood before they enter the CNS, an event that may represent a novel mechanism to guide leukocytes to sites for paracellular diapedesis across the BBB.
Sections du résumé
BACKGROUND
BACKGROUND
Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct intercellular solute and cellular movement. However, previous work from our laboratory found that claudin-5 (CLN-5), a TJ protein prominent at the blood-brain barrier (BBB), was also detected, ectopically, on leukocytes (CLN-5
METHODS
METHODS
To begin clarifying the significance of CLN-5
RESULTS
RESULTS
Flow cytometric analysis revealed CLN-5
CONCLUSION
CONCLUSIONS
Several leukocyte subtypes variably acquire CLN-5 in blood before they enter the CNS, an event that may represent a novel mechanism to guide leukocytes to sites for paracellular diapedesis across the BBB.
Identifiants
pubmed: 34933669
doi: 10.1186/s12974-021-02328-3
pii: 10.1186/s12974-021-02328-3
pmc: PMC8691042
doi:
Substances chimiques
Claudin-5
0
Cldn5 protein, mouse
0
Tight Junction Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
296Subventions
Organisme : NIH HHS
ID : R01 NS099855-01
Pays : United States
Informations de copyright
© 2021. The Author(s).
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