A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
received:
31
01
2020
accepted:
07
12
2021
entrez:
22
12
2021
pubmed:
23
12
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem cells (CSCs). Accordingly, potent, and selective inhibitors of key ALDH enzymes may represent a novel CSC-directed treatment paradigm for ALDH
Identifiants
pubmed: 34934174
doi: 10.1038/s42003-021-02949-7
pii: 10.1038/s42003-021-02949-7
pmc: PMC8692581
doi:
Substances chimiques
Tretinoin
5688UTC01R
Aldehyde Oxidoreductases
EC 1.2.-
aldehyde dehydrogenase (NAD(P)+)
EC 1.2.1.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1420Subventions
Organisme : NCI NIH HHS
ID : R01 CA238061
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : ES029518
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : CA148629
Organisme : NCI NIH HHS
ID : R01 CA148629
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM097082
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : ES014811
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : GM097082
Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR076924
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA012153
Pays : United States
Informations de copyright
© 2021. The Author(s).
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