Primary hyperparathyroidism-related giant parathyroid adenoma (Review).
calcium
cyst
giant parathyroid adenoma
incidentaloma
parathormone
parathyroid adenoma
parathyroid tumor
parathyroidectomy
primary hyperparathyroidism
vitamin D
Journal
Experimental and therapeutic medicine
ISSN: 1792-1015
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
06
08
2021
accepted:
07
09
2021
entrez:
22
12
2021
pubmed:
23
12
2021
medline:
23
12
2021
Statut:
ppublish
Résumé
Primary hyperparathyroidism (PHPT), an endocrine condition caused by a parathyroid adenoma (PTA) in 80-85% of the cases, has shifted in the modern era to a mildly symptomatic phenotype due to the prompt recognition of hypercalcemia and to a minimally invasive surgical approach which has a curative potential. Clinical complications of PHTH are either related to high calcium or parathyroid hormone [also parathormone (PTH)] or both, while the originating tumor typically is small, without local mass effects. A distinct entity is represented by giant PTA (GPTA) which is considered at a weight of more than 3 (3.5) grams. The present article is a review of the literature involving practical points of non-syndromic PHPT-related GPTA. Most authors agree that pre-operatory calcium and PTH are higher in GPTA vs. non-GPTA. However, the clinical presentation of PHPT may be less severe, probably due to local mass effects that bring the patient to an early medical evaluation. Age distribution, sex ratio, rate of successful pre-operatory location do not differ from non-giant PTA. Hypovitaminosis D is more frequent in PTA of higher dimensions. Post-operative hypocalcemia, but not recurrent/persistent PHPT, is expected, even hungry bone disease. A higher rate of atypia is described although the tumor is mostly benign. Unusual presentations such as cystic transformation, initial diagnosis during pregnancy or auto-infarction have been reported. The ectopic localization of PTA presented in almost 15% of all cases may also be found in GPTA. What are the exact cutoffs for defining GPTA is still an open issue.
Identifiants
pubmed: 34934453
doi: 10.3892/etm.2021.11011
pii: ETM-0-0-11011
pmc: PMC8652388
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
88Informations de copyright
Copyright © 2020, Spandidos Publications.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Int J Clin Exp Med. 2015 Jan 15;8(1):1501-3
pubmed: 25785164
BMC Endocr Disord. 2020 Apr 20;20(1):53
pubmed: 32312250
Int Surg. 2015 Jul;100(7-8):1185-9
pubmed: 26595491
Endokrynol Pol. 2020;71(4):359-360
pubmed: 32598023
Endocr Pract. 2012 Jan-Feb;18(1):e14-6
pubmed: 22068251
Langenbecks Arch Surg. 2019 Feb;404(1):63-70
pubmed: 30762091
Case Rep Pathol. 2019 Jun 13;2019:4383698
pubmed: 31312535
Case Rep Surg. 2018 Oct 23;2018:9261749
pubmed: 30425877
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):1929-1932
pubmed: 36452670
Exp Ther Med. 2020 Sep;20(3):2489-2492
pubmed: 32765740
J Clin Med. 2020 Aug 12;9(8):
pubmed: 32806580
Mol Imaging Radionucl Ther. 2019 Mar 19;28(1):41-43
pubmed: 30942063
Endocrinol Diabetes Metab Case Rep. 2014;2014:140086
pubmed: 25379182
Clin Otolaryngol. 2017 Apr;42(2):381-386
pubmed: 27696726
Indian J Nucl Med. 2012 Apr;27(2):122-3
pubmed: 23723587
Oncol Lett. 2016 Mar;11(3):2237-2240
pubmed: 26998155
Clin Endocrinol (Oxf). 2013 Jun;78(6):935-41
pubmed: 23046058
Acta Med Iran. 2016 Aug;54(8):547-550
pubmed: 27701727
Indian J Surg. 2013 Apr;75(2):102-5
pubmed: 24426402
Chonnam Med J. 2013 Dec;49(3):125-8
pubmed: 24400215
Ann R Coll Surg Engl. 2014 Oct;96(7):e8-10
pubmed: 25245714
JAMA Surg. 2016 Oct 1;151(10):959-968
pubmed: 27532368
Indian J Surg. 2013 Jun;75(Suppl 1):21-2
pubmed: 24426500
Indian J Surg. 2010 Apr;72(2):135-7
pubmed: 23133225
Lancet. 2009 Jul 11;374(9684):145-58
pubmed: 19595349
Surgery. 2013 Oct;154(4):714-8; discussion 718-9
pubmed: 23978594
Medicine (Baltimore). 2018 Jul;97(28):e11399
pubmed: 29995785
Ann R Coll Surg Engl. 2015 May;97(4):e64-6
pubmed: 26263956
Endocr Pract. 2015 Nov;21(11):1277-81
pubmed: 26307898
BMC Endocr Disord. 2012 Jul 28;12:14
pubmed: 22840059
J Emerg Trauma Shock. 2012 Apr;5(2):196-8
pubmed: 22787355
Indian J Nucl Med. 2016 Jan-Mar;31(1):36-8
pubmed: 26917892
J Med Life. 2016 Oct-Dec;9(4):348-352
pubmed: 27928436
J Surg Res. 2019 May;237:56-60
pubmed: 30694792
Chirurgia (Bucur). 2013 Nov-Dec;108(6):886-91
pubmed: 24331331
J Med Case Rep. 2016 Oct 19;10(1):286
pubmed: 27756436
Arch Endocrinol Metab. 2020 Apr;64(2):105-110
pubmed: 32236309
Endocrinol Diabetes Metab Case Rep. 2019 May 7;2019:
pubmed: 31063971
J Med Case Rep. 2017 Nov 29;11(1):333
pubmed: 29183364
Arch Iran Med. 2018 Nov 01;21(11):547-548
pubmed: 30551697
Arch Surg. 2010 Jul;145(7):705
pubmed: 20644137
BMJ Case Rep. 2013 Jun 21;2013:
pubmed: 23813580
J Am Coll Surg. 2015 Jun;220(6):1054-62
pubmed: 25488353
J Med Case Rep. 2019 Nov 14;13(1):332
pubmed: 31722742
Ann R Coll Surg Engl. 2020 May;102(5):363-368
pubmed: 32233846
Exp Ther Med. 2020 Oct;20(4):3389-3393
pubmed: 32905095
Exp Ther Med. 2020 Oct;20(4):3383-3388
pubmed: 32905002
Am J Case Rep. 2018 Nov 08;19:1334-1337
pubmed: 30405093
Medicine (Baltimore). 2019 Feb;98(5):e14351
pubmed: 30702624
Case Rep Womens Health. 2018 Nov 30;21:e00091
pubmed: 30591913
Ann R Coll Surg Engl. 2014 Jul;96(5):e21-3
pubmed: 24992407
Clin Case Rep. 2019 Mar 05;7(4):849-850
pubmed: 30997103
Eur J Nucl Med Mol Imaging. 2009 Jul;36(7):1201-16
pubmed: 19471928
Int J Surg Case Rep. 2017;31:262-265
pubmed: 28199935
Am J Surg. 2011 Aug;202(2):146-50
pubmed: 21256474
Endocr J. 2020 Jun 29;67(6):639-643
pubmed: 32213727
Surg Today. 2012 Dec;42(12):1183-8
pubmed: 22218874
BMJ Case Rep. 2019 Feb 7;12(2):
pubmed: 30737330
Turk Gogus Kalp Damar Cerrahisi Derg. 2020 Jan 23;28(1):217-218
pubmed: 32175168
BMJ Case Rep. 2016 Aug 17;2016:
pubmed: 27535730
Am Surg. 2015 Apr;81(4):E163-5
pubmed: 25831166
Ann Afr Med. 2021 Apr-Jun;20(2):150-153
pubmed: 34213485
Endocrinol Diabetes Metab Case Rep. 2013;2013:130019
pubmed: 24616763
Endocrinol Diabetes Metab Case Rep. 2017 May 06;2017:
pubmed: 28491324
Tuberk Toraks. 2011;59(3):263-5
pubmed: 22087523
Kathmandu Univ Med J (KUMJ). 2011 Jan-Mar;9(33):77-9
pubmed: 22610816
Case Rep Endocrinol. 2014;2014:213283
pubmed: 25610671
Ulus Cerrahi Derg. 2016 Mar 01;32(1):58-66
pubmed: 26985167
Acta Otorrinolaringol Esp. 2015 Sep-Oct;66(5):e28-30
pubmed: 24852512
Rom J Morphol Embryol. 2014;55(2 Suppl):669-74
pubmed: 25178342
Asian J Surg. 2020 Jul;43(7):759-764
pubmed: 31699571
J Med Life. 2010 Jul-Sep;3(3):308-13
pubmed: 20945822
Indian J Pathol Microbiol. 2015 Oct-Dec;58(4):487-90
pubmed: 26549073
Case Rep Med. 2010;2010:596185
pubmed: 21209735
Endocr Pract. 2021 Jun;27(6):614-620
pubmed: 34120702
Insights Imaging. 2014 Feb;5(1):103-11
pubmed: 24293304
Endocrine. 2016 May;52(2):399-400
pubmed: 26392005
Case Rep Med. 2012;2012:851941
pubmed: 22431942
BMC Endocr Disord. 2017 Jun 21;17(1):35
pubmed: 28637440
Med Ultrason. 2011 Sep;13(3):241-4
pubmed: 21894297
Int J Endocrinol. 2018 Jul 15;2018:3745239
pubmed: 30123260
Hormones (Athens). 2012 Oct-Dec;11(4):410-8
pubmed: 23422763
Ann Cardiothorac Surg. 2016 Jan;5(1):70-3
pubmed: 26904438
Cureus. 2020 Jan 31;12(1):e6830
pubmed: 32175203