The emerging role of selenium metabolic pathways in cancer: New therapeutic targets for cancer.
cancer therapy
glutathione peroxidase-4
selenocysteine
selenocysteine insertion sequence binding protein 2
thioredoxin reductase 1
Journal
Journal of cellular biochemistry
ISSN: 1097-4644
Titre abrégé: J Cell Biochem
Pays: United States
ID NLM: 8205768
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
11
11
2021
received:
02
10
2021
accepted:
07
12
2021
pubmed:
23
12
2021
medline:
14
4
2022
entrez:
22
12
2021
Statut:
ppublish
Résumé
Selenium (Se) is incorporated into the body via the selenocysteine (Sec) biosynthesis pathway, which is critical in the synthesis of selenoproteins, such as glutathione peroxidases and thioredoxin reductases. Selenoproteins, which play a key role in several biological processes, including ferroptosis, drug resistance, endoplasmic reticulum stress, and epigenetic processes, are guided by Se uptake. In this review, we critically analyze the molecular mechanisms of Se metabolism and its potential as a therapeutic target for cancer. Sec insertion sequence binding protein 2 (SECISBP2), which is a positive regulator for the expression of selenoproteins, would be a novel prognostic predictor and an alternate target for cancer. We highlight strategies that attempt to develop a novel Se metabolism-based approach to uncover a new metabolic drug target for cancer therapy. Moreover, we expect extensive clinical use of SECISBP2 as a specific biomarker in cancer therapy in the near future. Of note, scientists face additional challenges in conducting successful research, including investigations on anticancer peptides to target SECISBP2 intracellular protein.
Identifiants
pubmed: 34935169
doi: 10.1002/jcb.30196
pmc: PMC8940641
mid: NIHMS1764326
doi:
Substances chimiques
Carrier Proteins
0
Selenoproteins
0
Thioredoxin-Disulfide Reductase
EC 1.8.1.9
Selenium
H6241UJ22B
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
532-542Subventions
Organisme : NCI NIH HHS
ID : R21 CA259243
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA212125
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA205267
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA245171
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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