Antimicrobial agents in dental restorative materials: Effect on polymerization, short-term drug release and biological impact.
chlorhexidine diacetate
composite
high performance liquid chromatography
octinidine (di)hydrochloride
ormocer
Journal
European journal of oral sciences
ISSN: 1600-0722
Titre abrégé: Eur J Oral Sci
Pays: England
ID NLM: 9504563
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
16
06
2021
accepted:
22
10
2021
pubmed:
23
12
2021
medline:
6
5
2022
entrez:
22
12
2021
Statut:
ppublish
Résumé
With the aim to design bioactive dental restorative material, the present study investigated the influence of the antimicrobial agents chlorhexidine diacetate (CHX) and octinidine (di)hydrochloride (ODH) when incorporated in two different materials. Selected parameters were polymerization enthalpy, short-term drug release, and the effect on Streptococcus mutans as well as human gingival fibroblasts. Samples were made by mixing a nano-hybrid ormocer (O) and a methacrylate-based nano-hybrid composite (C), each with a mass fraction of 2% CHX or ODH. Release profiles and concentrations of active agents from the resins were assessed, and the cell proliferation of human gingival fibroblasts as well as Streptococcus mutans cultured with the eluates were evaluated. The influence on polymerization was assessed by means of differential scanning calorimetry. Both drugs, especially ODH, showed a decreasing effect on polymerization enthalpies associated with a lowered crosslinking degree. At the same time ODH appeared to be released more persistently than CHX. Moreover, ODH was more efficient with regard to bacteria growth inhibition but also more cytotoxic in terms of reduction of cell viability. ODH is deemed more appropriate for application in a dental resin-based drug delivery system, because of the more persistent drug release than seen for CHX.
Substances chimiques
Anti-Infective Agents
0
Composite Resins
0
Dental Materials
0
Chlorhexidine
R4KO0DY52L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12839Informations de copyright
© 2021 Scandinavian Division of the International Association for Dental Research. Published by John Wiley & Sons Ltd.
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