Interventions for Improving Body Composition in Men with Prostate Cancer: A Systematic Review and Network Meta-analysis.
Journal
Medicine and science in sports and exercise
ISSN: 1530-0315
Titre abrégé: Med Sci Sports Exerc
Pays: United States
ID NLM: 8005433
Informations de publication
Date de publication:
01 05 2022
01 05 2022
Historique:
pubmed:
23
12
2021
medline:
18
6
2022
entrez:
22
12
2021
Statut:
ppublish
Résumé
To perform a systematic review and network meta-analysis to investigate the most effective intervention for improving body composition outcomes in prostate cancer patients during or after treatment. A systematic search was undertaken in multiple databases from inception to December 2020. Randomized clinical trials examining the effects of exercise/physical activity and/or nutrition interventions on body composition and body weight measures in prostate cancer patients were included. The primary endpoints were both whole-body and regional fat mass and lean mass measures, with body weight and BMI as secondary outcomes. A frequentist random-effects network meta-analysis was undertaken to examine the clustering effect of intervention modalities or control groups on the outcomes of interest. The study protocol is publicly available on PROSPERO (CRD42020202339). Fifty articles describing 47 trials (n = 3207) were included. Resistance training and combined resistance and aerobic exercise were the most effective interventions to reduce body fat percentage (-0.9%; 95% confidence interval [CI], -1.4% to -0.3%) and fat mass (-0.5 kg; 95% CI, -0.9 to -0.1 kg), respectively. For whole-body and regional lean mass, combined resistance and aerobic exercise + healthy diet (0.6 kg; 95% CI, 0.1 to 1.0 kg) and resistance training alone (0.7 kg, 95% CI: 0.4 to 1.0 kg) were the best intervention, respectively. A low-fat diet was the most effective for reducing body weight immediately after or at follow-up, while no intervention promoted significant reductions in BMI. These results indicate that a resistance-based exercise program alone or combined with a general healthy diet are the most effective interventions for improving overall body composition in men with prostate cancer.
Identifiants
pubmed: 34935706
doi: 10.1249/MSS.0000000000002843
pii: 00005768-202205000-00003
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
728-740Informations de copyright
Copyright © 2021 by the American College of Sports Medicine.
Références
Galvao DA, Spry NA, Taaffe DR, et al. Changes in muscle, fat and bone mass after 36 weeks of maximal androgen blockade for prostate cancer. BJU Int . 2008;102(1):44–7.
Saylor PJ, Smith MR. Metabolic complications of androgen deprivation therapy for prostate cancer. J Urol . 2013;189(1 Suppl):S34–42; discussion S3–4.
Bhindi B, Locke J, Alibhai SMH, et al. Dissecting the association between metabolic syndrome and prostate cancer risk: analysis of a large clinical cohort. Eur Urol . 2015;67(1):64–70.
Di Bella CM, Howard LE, Oyekunle T, et al. Abdominal and pelvic adipose tissue distribution and risk of prostate cancer recurrence after radiation therapy. Prostate . 2020;80(14):1244–52.
Uchida T, Higure T, Kawakami M, et al. What factors affect the operative time of robot-assisted laparoscopic radical prostatectomy? Surg Endosc . 2021;35(8):4436–43.
Smith MR, Saad F, Egerdie B, et al. Sarcopenia during androgen-deprivation therapy for prostate cancer. J Clin Oncol . 2012;30(26):3271–6.
Nguyen PL, Alibhai SM, Basaria S, et al. Adverse effects of androgen deprivation therapy and strategies to mitigate them. Eur Urol . 2015;67(5):825–36.
Bonn SE, Wiklund F, Sjolander A, et al. Body mass index and weight change in men with prostate cancer: progression and mortality. Cancer Causes Control . 2014;25(8):933–43.
Cao Y, Ma J. Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis. Cancer Prev Res (Phila) . 2011;4(4):486–501.
Troeschel AN, Hartman TJ, Jacobs EJ, et al. Postdiagnosis body mass index, weight change, and mortality from prostate cancer, cardiovascular disease, and all causes among survivors of nonmetastatic prostate cancer. J Clin Oncol . 2020;38(18):2018–27.
Rock CL, Doyle C, Demark-Wahnefried W, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin . 2012;62(4):243–74.
Skolarus TA, Wolf AM, Erb NL, et al. American Cancer Society prostate cancer survivorship care guidelines. CA Cancer J Clin . 2014;64(4):225–49.
Ligibel JA, Alfano CM, Courneya KS, et al. American Society of Clinical Oncology position statement on obesity and cancer. J Clin Oncol . 2014;32(31):3568–74.
World Cancer Research Fund/American Institute for Cancer Prevention Research. Diet, nutrition, physical activity and cancer: a global perspective. Continuous update project expert report2018. Available at dietandcancerreport.org . Accessed June 2021.
Brown JC, Cespedes Feliciano EM, Caan BJ. The evolution of body composition in oncology-epidemiology, clinical trials, and the future of patient care: facts and numbers. J Cachexia Sarcopenia Muscle . 2018;9(7):1200–8.
Cushen SJ, Power DG, Murphy KP, et al. Impact of body composition parameters on clinical outcomes in patients with metastatic castrate-resistant prostate cancer treated with docetaxel. Clin Nutr ESPEN . 2016;13:e39–45.
Pak S, Park SY, Shin TJ, et al. Association of muscle mass with survival after radical prostatectomy in patients with prostate cancer. J Urol . 2019;202(3):525–32.
Lopez P, Newton RU, Taaffe DR, et al. Associations of fat and muscle mass with overall survival in men with prostate cancer: a systematic review with meta-analysis. Prostate Cancer Prostatic Dis . 2021.
Xu MC, Huelster HL, Hatcher JB, et al. Obesity is associated with longer survival independent of sarcopenia and myosteatosis in metastatic and/or castrate-resistant prostate cancer. J Urol . 2021;205(3):800–5.
Furlan AD, Pennick V, Bombardier C, van Tulder M; Editorial Board, Cochrane Back Review Group. 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group. Spine (Phila Pa 1976) . 2009;34(18):1929–41.
Hutton B, Salanti G, Caldwell DM, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med . 2015;162(11):777–84.
Lefebvre C, Manheimer E, Glanville J, Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1. 0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www cochrane-handbook org2011.
Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ . 2019;366:l4898.
Salanti G, Del Giovane C, Chaimani A, Caldwell DM, Higgins JP. Evaluating the quality of evidence from a network meta-analysis. PLoS One . 2014;9(7):e99682.
Rücker G. Network meta-analysis, electrical networks and graph theory. Res Synth Methods . 2012;3(4):312–24.
Shim SR, Kim SJ, Lee J, Rucker G. Network meta-analysis: application and practice using R software. Epidemiol Health . 2019;41:e2019013.
Rücker G, Schwarzer G. Ranking treatments in frequentist network meta-analysis works without resampling methods. BMC Med Res Methodol . 2015;15:58.
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ . 1997;315(7109):629–34.
Rucker G, Schwarzer G, Krahn U, Konig J. Network meta-analysis using frequentist methods. R package version 1.2.1.2017.
Link LB, Thompson SM, Bosland MC, Lumey LH. Adherence to a low-fat diet in men with prostate cancer. Urology . 2004;64(5):970–5.
Windsor PM, Nicol KF, Potter J. A randomized, controlled trial of aerobic exercise for treatment-related fatigue in men receiving radical external beam radiotherapy for localized prostate carcinoma. Cancer . 2004;101(3):550–7.
Ornish D, Weidner G, Fair WR, et al. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol . 2005;174(3):1065–9; discussion 9–70.
Carmack Taylor CL, Demoor C, Smith MA, et al. Active for life after cancer: a randomized trial examining a lifestyle physical activity program for prostate cancer patients. Psychooncology . 2006;15(10):847–62.
Lin DW, Neuhouser ML, Schenk JM, et al. Low-fat, low-glycemic load diet and gene expression in human prostate epithelium: a feasibility study of using cDNA microarrays to assess the response to dietary intervention in target tissues. Cancer Epidemiol Biomark Prev . 2007;16(10):2150–4.
Carmody J, Olendzki B, Reed G, Andersen V, Rosenzweig P. A dietary intervention for recurrent prostate cancer after definitive primary treatment: results of a randomized pilot trial. Urology . 2008;72(6):1324–8.
Li Z, Aronson WJ, Arteaga JR, et al. Feasibility of a low-fat/high-fiber diet intervention with soy supplementation in prostate cancer patients after prostatectomy. Eur J Clin Nutr . 2008;62(4):526–36.
Schenk JM, Neuhouser ML, Lin DW, Kristal AR. A dietary intervention to elicit rapid and complex dietary changes for studies investigating the effects of diet on tissues collected during invasive surgical procedures. J Am Diet Assoc . 2009;109(3):459–63.
Segal RJ, Reid RD, Courneya KS, et al. Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol . 2009;27(3):344–51.
Culos-Reed SN, Robinson JW, Lau H, et al. Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention. Support Care Cancer . 2010;18(5):591–9.
Galvão DA, Taaffe DR, Spry N, Joseph D, Newton RU. Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. J Clin Oncol . 2010;28(2):340–7.
Hébert JR, Hurley TG, Harmon BE, Heiney S, Hebert CJ, Steck SE. A diet, physical activity, and stress reduction intervention in men with rising prostate-specific antigen after treatment for prostate cancer. Cancer Epidemiol . 2012;36(2):e128–36.
Cormie P, Newton RU, Spry N, Joseph D, Taaffe DR, Galvão DA. Safety and efficacy of resistance exercise in prostate cancer patients with bone metastases. Prostate Cancer Prostatic Dis . 2013;16(4):328–35.
Santa Mina D, Alibhai SMH, Matthew AG, et al. A randomized trial of aerobic versus resistance exercise in prostate cancer survivors. J Aging Phys Act . 2013;21(4):455–78.
Wright JL, Plymate S, D’Oria-Cameron A, et al. A study of caloric restriction versus standard diet in overweight men with newly diagnosed prostate cancer: a randomized controlled trial. Prostate . 2013;73(12):1345–51.
Bourke L, Gilbert S, Hooper R, et al. Lifestyle changes for improving disease-specific quality of life in sedentary men on long-term androgen-deprivation therapy for advanced prostate cancer: a randomised controlled trial. Eur Urol . 2014;65(5):865–72.
Galvão DA, Spry N, Denham J, et al. A multicentre year-long randomised controlled trial of exercise training targeting physical functioning in men with prostate cancer previously treated with androgen suppression and radiation from TROG 03.04 RADAR. Eur Urol . 2014;65(5):856–64.
Jones LW, Hornsby WE, Freedland SJ, et al. Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer. Eur Urol . 2014;65(5):852–5.
Cormie P, Galvão DA, Spry N, et al. Can supervised exercise prevent treatment toxicity in patients with prostate cancer initiating androgen-deprivation therapy: a randomised controlled trial. BJU Int . 2015;115(2):256–66.
Nilsen TS, Raastad T, Skovlund E, et al. Effects of strength training on body composition, physical functioning, and quality of life in prostate cancer patients during androgen deprivation therapy. Acta Oncol . 2015;54(10):1805–13.
O’Neill RF, Haseen F, Murray LJ, O’Sullivan JM, Cantwell MM. A randomised controlled trial to evaluate the efficacy of a 6-month dietary and physical activity intervention for patients receiving androgen deprivation therapy for prostate cancer. J Cancer Surviv . 2015;9(3):431–40.
Winters-Stone KM, Dieckmann N, Maddalozzo GF, Bennett JA, Ryan CW, Beer TM. Resistance exercise reduces body fat and insulin during androgen-deprivation therapy for prostate cancer. Oncol Nurs Forum . 2015;42(4):348–56.
Hvid T, Lindegaard B, Winding K, et al. Effect of a 2-year home-based endurance training intervention on physiological function and PSA doubling time in prostate cancer patients. Cancer Causes Control . 2016;27(2):165–74.
Sajid S, Dale W, Mustian K, et al. Novel physical activity interventions for older patients with prostate cancer on hormone therapy: a pilot randomized study. J Geriatr Oncol . 2016;7(2):71–80.
Uth J, Hornstrup T, Christensen JF, et al. Efficacy of recreational football on bone health, body composition, and physical functioning in men with prostate cancer undergoing androgen deprivation therapy: 32-week follow-up of the FC prostate randomised controlled trial. Osteoporos Int . 2016;27(4):1507–18.
Winters-Stone KM, Lyons KS, Dobek J, et al. Benefits of partnered strength training for prostate cancer survivors and spouses: results from a randomized controlled trial of the exercising together project. J Cancer Surviv . 2016;10(4):633–44.
Demark-Wahnefried W, Rais-Bahrami S, Desmond RA, et al. Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer. Br J Cancer . 2017;117(9):1303–13.
Eriksen AK, Hansen RD, Borre M, et al. A lifestyle intervention among elderly men on active surveillance for non-aggressive prostate cancer: a randomised feasibility study with whole-grain rye and exercise. Trials . 2017;18(1):20.
Hojan K, Kwiatkowska-Borowczyk E, Leporowska E, Milecki P. Inflammation, cardiometabolic markers, and functional changes in men with prostate cancer. A randomized controlled trial of a 12-month exercise program. Pol Arch Intern Med . 2017;127(1):25–35.
Pernar CH, Fall K, Rider JR, et al. A walking intervention among men with prostate cancer: a pilot study. Clin Genitourin Cancer . 2017;15(6):e1021–8.
Bourke L, Stevenson R, Turner R, et al. Exercise training as a novel primary treatment for localised prostate cancer: a multi-site randomised controlled phase II study. Sci Rep . 2018;8(1):8374.
Dawson JK, Dorff TB, Todd Schroeder E, Lane CJ, Gross ME, Dieli-Conwright CM. Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial. BMC Cancer . 2018;18(1):368.
Focht BC, Lucas AR, Grainger E, et al. Effects of a group-mediated exercise and dietary intervention in the treatment of prostate cancer patients undergoing androgen deprivation therapy: results from the IDEA-P trial. Ann Behav Med . 2018;52(5):412–28.
Galvão DA, Newton RU, Girgis A, et al. Randomized controlled trial of a peer led multimodal intervention for men with prostate cancer to increase exercise participation. Psychooncology . 2018;27(1):199–207.
Galvão DA, Taaffe DR, Spry N, et al. Exercise preserves physical function in prostate cancer patients with bone metastases. Med Sci Sports Exerc . 2018;50(3):393–9.
Henning SM, Galet C, Gollapudi K, et al. Phase II prospective randomized trial of weight loss prior to radical prostatectomy. Prostate Cancer Prostatic Dis . 2018;21(2):212–20.
Santa Mina D, Hilton WJ, Matthew AG, et al. Prehabilitation for radical prostatectomy: a multicentre randomized controlled trial. Surg Oncol . 2018;27(2):289–98.
Bjerre ED, Brasso K, Jørgensen AB, et al. Football compared with usual care in men with prostate cancer (Fc prostate community trial): a pragmatic multicentre randomized controlled trial. Sports Med . 2019;49(1):145–58.
Freedland SJ, Howard L, Allen J, et al. A lifestyle intervention of weight loss via a low-carbohydrate diet plus walking to reduce metabolic disturbances caused by androgen deprivation therapy among prostate cancer patients: carbohydrate and prostate study 1 (CAPS1) randomized controlled trial. Prostate Cancer Prostatic Dis . 2019;22(3):428–37.
Mohamad H, Ntessalen M, Craig LCA, et al. A self-help diet and physical activity intervention with dietetic support for weight management in men treated for prostate cancer: pilot study of the prostate cancer weight management (PRO-MAN) randomised controlled trial. Br J Nutr . 2019;122(5):592–600.
Newton RU, Galvão DA, Spry N, et al. Exercise mode specificity for preserving spine and hip bone mineral density in prostate cancer patients. Med Sci Sports Exerc . 2019;51(4):607–14.
Taaffe DR, Galvão DA, Spry N, et al. Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition. BJU Int . 2019;123(2):261–9.
Villumsen BR, Jorgensen MG, Frystyk J, Hørdam B, Borre M. Home-based ‘exergaming’ was safe and significantly improved 6-min walking distance in patients with prostate cancer: a single-blinded randomised controlled trial. BJU Int . 2019;124(4):600–8.
Freedland SJ, Allen J, Jarman A, et al. A randomized controlled trial of a 6-month low-carbohydrate intervention on disease progression in men with recurrent prostate cancer: carbohydrate and prostate study 2 (CAPS2). Clin Cancer Res . 2020;26(12):3035–43.
Lim JJ, Kim YS, Choi HY, et al. Lifestyle intervention for promoting physical activity in prostate cancer patients with androgen deprivation therapy. J Men’s Health . 2020;16(4):e54–64.
Ndjavera W, Orange ST, O’Doherty AF, et al. Exercise-induced attenuation of treatment side-effects in patients with newly diagnosed prostate cancer beginning androgen-deprivation therapy: a randomised controlled trial. BJU Int . 2020;125(1):28–37.
Baguley BJ, Skinner TL, Jenkins DG, Wright ORL. Mediterranean-style dietary pattern improves cancer-related fatigue and quality of life in men with prostate cancer treated with androgen deprivation therapy: a pilot randomised control trial. Clin Nutr . 2021;40(1):245–54.
Gilbert SE, Tew GA, Fairhurst C, et al. Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer. Br J Cancer . 2016;114(4):401–8.
Uth J, Fristrup B, Haahr RD, et al. Football training over 5 years is associated with preserved femoral bone mineral density in men with prostate cancer. Scand J Med Sci Sports . 2018;28(1 Suppl):61–73.
Bjerre ED, Petersen TH, Jørgensen AB, et al. Community-based football in men with prostate cancer: 1-year follow-up on a pragmatic, multicentre randomised controlled trial. PLoS Med . 2019;16(10):e1002936.
Cormie P, Atkinson M, Bucci L, et al. Clinical oncology Society of Australia position statement on exercise in cancer care. Med J Aust . 2018;209(4):184–7.
Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc . 2019;51(11):2375–90.
Hayes SC, Newton RU, Spence RR, Galvao DA. The exercise and sports science Australia position statement: exercise medicine in cancer management. J Sci Med Sport . 2019;22(11):1175–99.
Schmitz KH, Campbell AM, Stuiver MM, et al. Exercise is medicine in oncology: engaging clinicians to help patients move through cancer. CA Cancer J Clin . 2019;69(6):468–84.
Wilson RL, Newton RU, Taaffe DR, Hart NH, Lyons-Wall P, GalvÃo DA. Weight loss for obese prostate cancer patients on androgen deprivation therapy. Med Sci Sports Exerc . 2021;53(3):470–8.
Farris MS, Courneya KS, Kopciuk KA, McGregor SE, Friedenreich CM. Anthropometric measurements and survival after a prostate cancer diagnosis. Br J Cancer . 2018;118(4):607–10.
Zhong S, Yan X, Wu Y, et al. Body mass index and mortality in prostate cancer patients: a dose-response meta-analysis. Prostate Cancer Prostatic Dis . 2016;19(2):122–31.
Lennon H, Sperrin M, Badrick E, Renehan AG. The obesity paradox in cancer: a review. Curr Oncol Rep . 2016;18(9):56.
Bigaran A, Zopf E, Gardner J, et al. The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis . 2020;24(1):35–48.
Lopez P, Taaffe DR, Newton RU, Galvao DA. Resistance exercise dosage in men with prostate cancer: systematic review, meta-analysis, and meta-regression. Med Sci Sports Exerc . 2021;53(3):459–69.
Galvão DA, Taaffe DR, Newton RU. Body weight, fat mass and metabolic complications during androgen deprivation therapy: should urologists recommend exercise and diet to help patients overcome toxicities? Prostate Cancer Prostatic Dis . 2021;24(3):591–3.
Pak S, Kim MS, Park EY, Kim SH, Lee KH, Joung JY. Association of body composition with survival and treatment efficacy in castration-resistant prostate cancer. Front Oncol . 2020;10:558.
Ohtaka A, Aoki H, Nagata M, et al. Sarcopenia is a poor prognostic factor of castration-resistant prostate cancer treated with docetaxel therapy. Prostate Int . 2019;7(1):9–14.
Koelwyn GJ, Quail DF, Zhang X, White RM, Jones LW. Exercise-dependent regulation of the tumour microenvironment. Nat Rev Cancer . 2017;17(10):620–32.
Prado CM, Purcell SA, Alish C, et al. Implications of low muscle mass across the continuum of care: a narrative review. Ann Med . 2018;50(8):675–93.
Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol . 2018;14(9):513–37.
Owen PJ, Daly RM, Dalla Via J, et al. Does use of androgen deprivation therapy (ADT) in men with prostate cancer increase the risk of sarcopenia? Calcif Tissue Int . 2019;105(4):403–11.
LeVasseur N, Cheng W, Mazzarello S, et al. Optimising weight-loss interventions in cancer patients—a systematic review and network meta-analysis. PLoS One . 2021;16(2):e0245794.
Wilson RL, Shannon T, Calton E, et al. Efficacy of a weight loss program prior to robot assisted radical prostatectomy in overweight and obese men with prostate cancer. Surg Oncol . 2020;35:182–8.