Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
24 Dec 2021
24 Dec 2021
Historique:
entrez:
22
12
2021
pubmed:
23
12
2021
medline:
23
12
2021
Statut:
ppublish
Résumé
Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death. Underlying biological processes involve induced massive deposition of extracellular matrix (ECM) by aberrant fibroblasts. We subjected diseased primary human lung fibroblasts to an advanced three-dimensional phenotypic high-content assay and screened a repurposing drug library of small molecules for inhibiting ECM deposition. Fibrotic Pattern Detection by Artificial Intelligence identified tranilast as an effective inhibitor. Structure-activity relationship studies confirmed
Identifiants
pubmed: 34936468
doi: 10.1126/sciadv.abb3673
pmc: PMC8694600
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabb3673Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL146519
Pays : United States
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