Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration.
Animals
Astrocytes
/ cytology
Calcium
/ metabolism
Calcium Channels
/ physiology
Calcium Signaling
Cannabinoids
/ metabolism
Cells, Cultured
Endoplasmic Reticulum
/ metabolism
Hippocampus
/ metabolism
Homeostasis
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
Neuronal Plasticity
Receptors, Cannabinoid
/ physiology
Synapses
/ physiology
Synaptic Transmission
CB1
MERCs
astrocytes
calcium
cannabinoid
lateral synaptic potentiation
mitochondria
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
received:
16
07
2020
revised:
08
10
2021
accepted:
23
11
2021
entrez:
22
12
2021
pubmed:
23
12
2021
medline:
16
2
2022
Statut:
ppublish
Résumé
Intracellular calcium signaling underlies the astroglial control of synaptic transmission and plasticity. Mitochondria-endoplasmic reticulum contacts (MERCs) are key determinants of calcium dynamics, but their functional impact on astroglial regulation of brain information processing is unexplored. We found that the activation of astrocyte mitochondrial-associated type-1 cannabinoid (mtCB
Identifiants
pubmed: 34936875
pii: S2211-1247(21)01629-6
doi: 10.1016/j.celrep.2021.110133
pii:
doi:
Substances chimiques
Calcium Channels
0
Cannabinoids
0
Receptors, Cannabinoid
0
mitochondrial calcium uniporter
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110133Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.