Surface phenotypes of naive and memory B cells in mouse and human tissues.
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
30
01
2021
accepted:
22
10
2021
pubmed:
24
12
2021
medline:
22
2
2022
entrez:
23
12
2021
Statut:
ppublish
Résumé
Memory B cells (MBCs) protect the body from recurring infections. MBCs differ from their naive counterparts (NBCs) in many ways, but functional and surface marker differences are poorly characterized. In addition, although mice are the prevalent model for human immunology, information is limited concerning the nature of homology in B cell compartments. To address this, we undertook an unbiased, large-scale screening of both human and mouse MBCs for their differential expression of surface markers. By correlating the expression of such markers with extensive panels of known markers in high-dimensional flow cytometry, we comprehensively identified numerous surface proteins that are differentially expressed between MBCs and NBCs. The combination of these markers allows for the identification of MBCs in humans and mice and provides insight into their functional differences. These results will greatly enhance understanding of humoral immunity and can be used to improve immune monitoring.
Identifiants
pubmed: 34937918
doi: 10.1038/s41590-021-01078-x
pii: 10.1038/s41590-021-01078-x
pmc: PMC8712407
mid: NIHMS1755109
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-145Subventions
Organisme : NIAID NIH HHS
ID : P01 AI106697
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI043603
Pays : United States
Informations de copyright
© 2021. Springer Nature America, Inc.
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