Association Between Triglyceride-Glucose Index and Risk of Periodontitis: A Cross-Sectional Study.
NHANES
periodontitis
propensity score matching
triglyceride-glucose index
Journal
International journal of general medicine
ISSN: 1178-7074
Titre abrégé: Int J Gen Med
Pays: New Zealand
ID NLM: 101515487
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
09
2021
accepted:
01
12
2021
entrez:
23
12
2021
pubmed:
24
12
2021
medline:
24
12
2021
Statut:
epublish
Résumé
The purpose of this study was to investigate the TyG index in the occurrence of periodontitis among the United States (US) population. We analyzed clinical data from 4813 participants in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2014. the TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Dose-response curves, univariate and multivariate logistic analyses were used to analyze the adjusted odds ratio (aOR) and 95% confidence interval (CI) between TyG index and periodontitis. In addition, we performed 1:1 propensity score matching (PSM) for periodontitis and no periodontitis participants to further explore the relationship between TyG and periodontitis. A total of 4813 participants were included in our study, of which 1353 (28.1%) reported periodontitis and 3460 (71.9%) no periodontitis. The dose-response curves showed a non-linear positive association between TyG and periodontitis, with the risk of periodontitis increased with increasing TyG. In addition, similar results were still observed after subgroup analysis and PSM analysis. After adjusting for confounding variables, multivariate logistic analysis showed that TyG was associated with an increased risk of periodontitis (aOR =1.153; 95% CI 1.006-1.322, p=0.034). Elevated TyG index was significantly associated with a high risk of periodontitis, and people with a high TyG index should be aware of the risk of periodontitis progression in order to establish lifestyle changes at an early stage.
Sections du résumé
BACKGROUND
BACKGROUND
The purpose of this study was to investigate the TyG index in the occurrence of periodontitis among the United States (US) population.
METHODS
METHODS
We analyzed clinical data from 4813 participants in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2014. the TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Dose-response curves, univariate and multivariate logistic analyses were used to analyze the adjusted odds ratio (aOR) and 95% confidence interval (CI) between TyG index and periodontitis. In addition, we performed 1:1 propensity score matching (PSM) for periodontitis and no periodontitis participants to further explore the relationship between TyG and periodontitis.
RESULTS
RESULTS
A total of 4813 participants were included in our study, of which 1353 (28.1%) reported periodontitis and 3460 (71.9%) no periodontitis. The dose-response curves showed a non-linear positive association between TyG and periodontitis, with the risk of periodontitis increased with increasing TyG. In addition, similar results were still observed after subgroup analysis and PSM analysis. After adjusting for confounding variables, multivariate logistic analysis showed that TyG was associated with an increased risk of periodontitis (aOR =1.153; 95% CI 1.006-1.322, p=0.034).
CONCLUSION
CONCLUSIONS
Elevated TyG index was significantly associated with a high risk of periodontitis, and people with a high TyG index should be aware of the risk of periodontitis progression in order to establish lifestyle changes at an early stage.
Identifiants
pubmed: 34938103
doi: 10.2147/IJGM.S339863
pii: 339863
pmc: PMC8687520
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9807-9816Informations de copyright
© 2021 Li et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Autoimmun Rev. 2018 Apr;17(4):376-390
pubmed: 29428807
J Clin Periodontol. 2010 Jul;37(7):601-8
pubmed: 20492076
Cardiovasc Diabetol. 2017 Mar 1;16(1):30
pubmed: 28249577
Stat Med. 2007 Jul 20;26(16):3078-94
pubmed: 17187347
Arch Med Res. 2016 Jul;47(5):382-387
pubmed: 27751372
Nat Rev Immunol. 2015 Jan;15(1):30-44
pubmed: 25534621
Diabetes Res Clin Pract. 2011 Sep;93(3):e98-e100
pubmed: 21665314
Front Endocrinol (Lausanne). 2020 Jun 09;11:336
pubmed: 32582028
Int J Gen Med. 2021 Sep 29;14:6233-6244
pubmed: 34616176
Cardiovasc Diabetol. 2020 May 6;19(1):53
pubmed: 32375783
ScientificWorldJournal. 2014 Jan 08;2014:768237
pubmed: 24526921
Anesthesiology. 2008 Mar;108(3):506-23
pubmed: 18292688
Cell Metab. 2011 Nov 2;14(5):575-85
pubmed: 22055501
Diabetes Care. 2000 Jan;23(1):57-63
pubmed: 10857969
Nat Rev Dis Primers. 2017 Jun 22;3:17038
pubmed: 28805207
Dis Markers. 2014;2014:930206
pubmed: 24692844
Lancet. 2004 Jul 10-16;364(9429):149-55
pubmed: 15246727
Diabetes Metab J. 2012 Dec;36(6):404-11
pubmed: 23275933
J Dent Res. 2012 Oct;91(10):914-20
pubmed: 22935673
Transl Androl Urol. 2021 Jan;10(1):77-86
pubmed: 33532298
Front Mol Biosci. 2020 Dec 14;7:609806
pubmed: 33381523
Metab Syndr Relat Disord. 2008 Dec;6(4):299-304
pubmed: 19067533
J Adv Res. 2020 Feb 26;27:19-30
pubmed: 33318863
Arch Oral Biol. 2014 Aug;59(8):855-70
pubmed: 24880501
Metab Syndr Relat Disord. 2021 Mar;19(2):76-82
pubmed: 33170086
Ecotoxicol Environ Saf. 2021 Jan 15;208:111497
pubmed: 33091773
Clin Microbiol Infect. 2007 Oct;13 Suppl 4:3-10
pubmed: 17716290
Braz Oral Res. 2018 May 24;32:e35
pubmed: 29846383
J Pediatr Endocrinol Metab. 2020 May 24;33(6):777-784
pubmed: 32447329
J Assoc Physicians India. 2020 Oct;68(10):29-33
pubmed: 32978922
Cardiovasc Diabetol. 2017 Aug 23;16(1):108
pubmed: 28830471
J Periodontol. 2015 May;86(5):611-22
pubmed: 25688694
J Immunol Res. 2015;2015:615486
pubmed: 26065002
Diabetes Metab Syndr. 2015 Apr-Jun;9(2):124-6
pubmed: 25796974
Sci Rep. 2021 May 11;11(1):10036
pubmed: 33976344
Clin Biochem Rev. 2005 May;26(2):19-39
pubmed: 16278749
J Pharm Bioallied Sci. 2012 Aug;4(Suppl 2):S280-2
pubmed: 23066270
Eat Weight Disord. 2018 Dec;23(6):877-883
pubmed: 29453589
Dent J (Basel). 2019 Dec 11;7(4):
pubmed: 31835888
J Clin Endocrinol Metab. 2010 Jul;95(7):3347-51
pubmed: 20484475