Absence of
GSTT1-absent
GSTT1-present
breast cancer
molecular epidemiology
null genotype
polymorphism
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
03
2021
accepted:
01
11
2021
entrez:
23
12
2021
pubmed:
24
12
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Deletion of Glutathione S-Transferase Theta 1 (GSTT1) encoding gene is implicated in breast cancer susceptibility, clinical outcomes, and survival. Contradictory results have been reported in different studies. The present investigation based on a representative Pakistani population evaluated the A prospective study comprising case-control analysis and case series analysis components was designed. Peripheral blood samples were collected from enrolled participants. After DNA extraction, A total of 264 participants were enrolled in the molecular investigation (3 institutions). The study included 121 primary breast cancer patients as cases and 143 age-matched female subjects, with no history of any cancer, as controls. A significant genetic association between The present study is the first report of an independent significant genetic association between
Identifiants
pubmed: 34938652
doi: 10.3389/fonc.2021.678705
pmc: PMC8685396
doi:
Types de publication
Journal Article
Langues
eng
Pagination
678705Informations de copyright
Copyright © 2021 Ajaz, Zaidi, Ali, Siddiqa, Memon, Firasat, Abid and Khaliq.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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