Roles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base.
orbital malignant tumors
particle radiotherapy
skull base surgery
Journal
Laryngoscope investigative otolaryngology
ISSN: 2378-8038
Titre abrégé: Laryngoscope Investig Otolaryngol
Pays: United States
ID NLM: 101684963
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
04
09
2021
revised:
30
09
2021
accepted:
05
10
2021
entrez:
23
12
2021
pubmed:
24
12
2021
medline:
24
12
2021
Statut:
epublish
Résumé
To investigate the oncological outcomes of orbital malignant tumors invading the skull base. A retrospective analysis was conducted on 16 patients with orbital malignant tumors invading the skull base. Eleven patients were treated with skull base surgery, four patients were treated with particle therapies, and one patient was treated with chemoradiotherapy (CRT) as initial treatment. The most frequent histological type was adenoid cystic carcinoma in seven patients, followed by squamous cell carcinoma in two patients. Local recurrence occurred in two of the six surgically treated patients who did not receive postoperative radiotherapy (RT) or CRT. One of them was successfully salvaged by RT, and the other died of disease. With a median follow-up of 24 months, the 2-year overall, local control, and disease-free survival rates of all patients were 82.5%, 87.5%, and 59%, respectively. Patients with positive surgical margins were at risk of local recurrence. Postoperative RT should be considered for all surgically treated patients.Level of Evidence: 4.
Identifiants
pubmed: 34938873
doi: 10.1002/lio2.687
pii: LIO2687
pmc: PMC8665474
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1347-1352Informations de copyright
© 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.
Déclaration de conflit d'intérêts
The authors declare no potential conflict of interest.
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