New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis.
antifungal therapy
caspofungin
mucoadhesive hydrogel
thermoreversible hydrogel
vaginal mucosal delivery
vulvovaginal candidiasis
Journal
Gels (Basel, Switzerland)
ISSN: 2310-2861
Titre abrégé: Gels
Pays: Switzerland
ID NLM: 101696925
Informations de publication
Date de publication:
12 Dec 2021
12 Dec 2021
Historique:
received:
03
11
2021
revised:
03
12
2021
accepted:
07
12
2021
entrez:
23
12
2021
pubmed:
24
12
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Vulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The formulations were physically, mechanically and morphologically characterized. Drug release profile and ex vivo vaginal permeation studies were performed. Antifungal efficacy against different strains of
Identifiants
pubmed: 34940319
pii: gels7040259
doi: 10.3390/gels7040259
pmc: PMC8701247
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Spanish National Research Council
ID : 202080E231
Références
Pathog Dis. 2019 Jun 1;77(4):
pubmed: 31374574
Polymers (Basel). 2020 Dec 23;13(1):
pubmed: 33374756
Eur J Pharm Biopharm. 2010 Oct;76(2):296-303
pubmed: 20656027
Lancet. 2007 Jun 9;369(9577):1961-71
pubmed: 17560449
Pharm Res. 2006 Dec;23(12):2709-28
pubmed: 17096184
Molecules. 2020 Mar 27;25(7):
pubmed: 32230990
Pharm Res. 2017 May;34(5):1067-1082
pubmed: 28168390
Drug Deliv. 2016 Nov;23(9):3544-3551
pubmed: 27340764
Int J Pharm. 1999 May 10;182(1):21-32
pubmed: 10332071
Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):42-8
pubmed: 21612898
Eur J Pharm Biopharm. 2017 Mar;112:143-147
pubmed: 27890510
Eur J Pharm Sci. 2021 Apr 1;159:105722
pubmed: 33482314
Polymers (Basel). 2017 Apr 12;9(4):
pubmed: 30970818
Eur J Pharm Sci. 2009 Mar 2;36(4-5):591-601
pubmed: 19150403
Curr Pharm Des. 2015;21(29):4285-309
pubmed: 26323422
Microb Biotechnol. 2009 Mar;2(2):186-201
pubmed: 21261913
J Drug Target. 2018 Nov;26(9):829-839
pubmed: 29378463
J Funct Biomater. 2018 Jan 18;9(1):
pubmed: 29346330
Int J Nanomedicine. 2014 Jun 28;9:3151-61
pubmed: 25061292
Biomed Res Int. 2017;2017:3564060
pubmed: 29209627
Eur J Pharm Sci. 2021 Dec 1;167:106011
pubmed: 34537375
J Control Release. 2018 Jan 28;270:145-157
pubmed: 29223536
Pharmaceutics. 2021 Sep 02;13(9):
pubmed: 34575468
Eur J Pharm Sci. 2013 Sep 27;50(1):29-41
pubmed: 23684936
Am J Clin Pathol. 1966 Apr;45(4):493-6
pubmed: 5325707
Nanomedicine (Lond). 2015 Jan;10(2):227-40
pubmed: 25600968
Pharm Dev Technol. 2020 Dec;25(10):1238-1248
pubmed: 32787718
Pharmacognosy Res. 2017 Jan-Mar;9(1):12-20
pubmed: 28250648
Antimicrob Agents Chemother. 2011 Apr;55(4):1761-3
pubmed: 21263052
Mar Drugs. 2015 Sep 16;13(9):5901-19
pubmed: 26389926
J Oral Biol Craniofac Res. 2018 May-Aug;8(2):126-133
pubmed: 29892535
Mycopathologia. 2020 Aug;185(4):599-606
pubmed: 32737747
Appl Environ Microbiol. 2008 Jun;74(12):3764-73
pubmed: 18456858
Biomed Pharmacother. 2016 Oct;83:485-495
pubmed: 27434864
Pharmaceutics. 2020 Jun 19;12(6):
pubmed: 32575388
Polymers (Basel). 2016 Nov 21;8(11):
pubmed: 30974683
Int J Pharm. 2018 Jan 15;535(1-2):393-401
pubmed: 29146542
Molecules. 2020 Sep 01;25(17):
pubmed: 32882899
Nat Rev Immunol. 2020 Oct;20(10):587-588
pubmed: 32778829
J Infect Dis. 2017 Mar 1;215(5):723-731
pubmed: 28007924
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:886-893
pubmed: 28629093
Materials (Basel). 2020 Apr 06;13(7):
pubmed: 32268504
Materials (Basel). 2021 Aug 12;14(16):
pubmed: 34443046
J Antimicrob Chemother. 2018 Sep 1;73(9):2493-2496
pubmed: 29860319
J Biomater Sci Polym Ed. 2007;18(11):1429-41
pubmed: 17961325
Adv Drug Deliv Rev. 2005 Nov 3;57(11):1583-94
pubmed: 16169120
Antimicrob Agents Chemother. 2020 Aug 20;64(9):
pubmed: 32601169
Lancet. 2003 Oct 4;362(9390):1142-51
pubmed: 14550704
Int J Pharm. 2013 Oct 1;454(2):695-702
pubmed: 23792467
Front Microbiol. 2021 Jun 21;12:652725
pubmed: 34234752
Sci Rep. 2019 Aug 12;9(1):11658
pubmed: 31406233
Colloids Surf B Biointerfaces. 2019 Mar 1;175:365-374
pubmed: 30554015
J Fungi (Basel). 2020 Oct 08;6(4):
pubmed: 33050019
J Mater Sci Mater Med. 2018 Oct 22;29(11):158
pubmed: 30349982
Sci Transl Med. 2012 Jun 13;4(138):138ra79
pubmed: 22700955
Int J Biol Macromol. 2020 Jan 1;142:412-422
pubmed: 31593719
Clin Infect Dis. 2003 Jun 1;36(11):1445-57
pubmed: 12766841
Methods Mol Biol. 2017;1508:107-139
pubmed: 27837500
Int J Nanomedicine. 2020 Jun 11;15:4079-4090
pubmed: 32606665
Eur J Pharm Sci. 2018 Jan 1;111:358-375
pubmed: 28986195
Molecules. 2019 Jul 12;24(14):
pubmed: 31336916
Acta Pharm Sin B. 2017 Jul;7(4):502-509
pubmed: 28752037
Biomacromolecules. 2017 Nov 13;18(11):3846-3868
pubmed: 28933147
Adv Drug Deliv Rev. 2015 Sep 15;92:2-13
pubmed: 25933938
Eur J Pharm Sci. 2014 Aug 18;60:49-54
pubmed: 24813111
Drugs. 2004;64(18):1997-2020
pubmed: 15341494
Pharmaceutics. 2018 Sep 12;10(3):
pubmed: 30213143
Colloids Surf B Biointerfaces. 2008 May 1;63(1):1-6
pubmed: 18314312
Gels. 2021 Jan 23;7(1):
pubmed: 33498627
J Antimicrob Chemother. 2014 Dec;69(12):3294-9
pubmed: 25139840
J Clin Microbiol. 2004 Oct;42(10):4419-31
pubmed: 15472288
Drugs. 2005;65(14):2049-68
pubmed: 16162025
Int J Mol Sci. 2021 Aug 04;22(16):
pubmed: 34445090
Drugs. 2011 Jan 1;71(1):11-41
pubmed: 21175238
J Antimicrob Chemother. 2003 Mar;51(3):513-21
pubmed: 12615851
Folia Microbiol (Praha). 2019 Mar;64(2):133-141
pubmed: 30269301
Pharmaceutics. 2020 Feb 12;12(2):
pubmed: 32059430