Synthetic Cell as a Platform for Understanding Membrane-Membrane Interactions.
lipid bilayer membrane
membrane fusion
membrane proteins
synthetic cell communications
synthetic cells
Journal
Membranes
ISSN: 2077-0375
Titre abrégé: Membranes (Basel)
Pays: Switzerland
ID NLM: 101577807
Informations de publication
Date de publication:
23 Nov 2021
23 Nov 2021
Historique:
received:
20
10
2021
revised:
10
11
2021
accepted:
16
11
2021
entrez:
23
12
2021
pubmed:
24
12
2021
medline:
24
12
2021
Statut:
epublish
Résumé
In the pursuit of understanding life, model membranes made of phospholipids were envisaged decades ago as a platform for the bottom-up study of biological processes. Micron-sized lipid vesicles have gained great acceptance as their bilayer membrane resembles the natural cell membrane. Important biological events involving membranes, such as membrane protein insertion, membrane fusion, and intercellular communication, will be highlighted in this review with recent research updates. We will first review different lipid bilayer platforms used for incorporation of integral membrane proteins and challenges associated with their functional reconstitution. We next discuss different methods for reconstitution of membrane fusion and compare their fusion efficiency. Lastly, we will highlight the importance and challenges of intercellular communication between synthetic cells and synthetic cells-to-natural cells. We will summarize the review by highlighting the challenges and opportunities associated with studying membrane-membrane interactions and possible future research directions.
Identifiants
pubmed: 34940413
pii: membranes11120912
doi: 10.3390/membranes11120912
pmc: PMC8706075
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Science Foundation
ID : 1935265
Organisme : NIH HHS
ID : R01 EB030031
Pays : United States
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