New Insights to the Crosstalk between Vascular and Bone Tissue in Chronic Kidney Disease-Mineral and Bone Disorder.
TGF-β signaling
Wnt pathway
activin A
dickkopf-1
renal osteodystrophy
sclerostin
tissue crosstalk
uremic vasculopathy
vascular calcification
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
07 Dec 2021
07 Dec 2021
Historique:
received:
28
10
2021
revised:
30
11
2021
accepted:
02
12
2021
entrez:
23
12
2021
pubmed:
24
12
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Vasculature plays a key role in bone development and the maintenance of bone tissue throughout life. The two organ systems are not only linked in normal physiology, but also in pathophysiological conditions. The chronic kidney disease-mineral and bone disorder (CKD-MBD) is still the most serious complication to CKD, resulting in increased morbidity and mortality. Current treatment therapies aimed at the phosphate retention and parathyroid hormone disturbances fail to reduce the high cardiovascular mortality in CKD patients, underlining the importance of other factors in the complex syndrome. This review will focus on vascular disease and its interplay with bone disorders in CKD. It will present the very late data showing a direct effect of vascular calcification on bone metabolism, indicating a vascular-bone tissue crosstalk in CKD. The calcified vasculature not only suffers from the systemic effects of CKD but seems to be an active player in the CKD-MBD syndrome impairing bone metabolism and might be a novel target for treatment and prevention.
Identifiants
pubmed: 34940607
pii: metabo11120849
doi: 10.3390/metabo11120849
pmc: PMC8708186
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Nat Med. 2018 Jun;24(6):823-833
pubmed: 29785024
FASEB J. 2007 Sep;21(11):2949-60
pubmed: 17449718
Curr Opin Hematol. 2017 May;24(3):230-239
pubmed: 28212189
J Bone Miner Res. 2019 Feb;34(2):270-281
pubmed: 30216554
Int J Mol Sci. 2019 Sep 07;20(18):
pubmed: 31500313
Development. 2016 Aug 1;143(15):2706-15
pubmed: 27486231
BMC Nephrol. 2019 Jul 17;20(1):266
pubmed: 31315601
J Bone Miner Res. 2013 Aug;28(8):1760-70
pubmed: 23408601
J Clin Med. 2020 Nov 01;9(11):
pubmed: 33139598
Am J Pathol. 2019 Aug;189(8):1495-1500
pubmed: 31345466
J Bone Miner Res. 2003 Jan;18(1):47-57
pubmed: 12510805
J Am Soc Nephrol. 2014 Aug;25(8):1760-73
pubmed: 24578135
Cell Biol Int. 2005 Jul;29(7):583-5
pubmed: 15979904
J Bone Miner Res. 2016 Jan;31(1):129-42
pubmed: 26235988
Pflugers Arch. 2019 Aug;471(8):1079-1094
pubmed: 31236663
Kidney Int. 2017 Jul;92(1):165-178
pubmed: 28341272
Cell. 1997 Apr 18;89(2):309-19
pubmed: 9108485
Physiol Rev. 2019 Jan 1;99(1):739-780
pubmed: 30540228
Bone Res. 2021 Mar 22;9(1):21
pubmed: 33753717
Biochem Biophys Res Commun. 1998 Dec 18;253(2):395-400
pubmed: 9878548
Cardiovasc Diabetol. 2014 Apr 07;13:74
pubmed: 24708830
Nephrol Dial Transplant. 2008 Feb;23(2):586-93
pubmed: 17933842
Cells. 2021 Aug 13;10(8):
pubmed: 34440850
Osteoporos Int. 2015 Aug;26(8):2165-74
pubmed: 25910747
Kidney Int. 2015 Jun;87(6):1089-91
pubmed: 26024025
Am J Physiol Renal Physiol. 2018 May 1;314(5):F753-F762
pubmed: 29187373
J Bone Miner Res. 2012 Aug;27(8):1757-72
pubmed: 22492547
Cell Res. 1998 Sep;8(3):171-7
pubmed: 9791730
Sci Rep. 2016 Jul 19;6:29880
pubmed: 27430980
Front Cardiovasc Med. 2019 Jan 18;5:196
pubmed: 30713844
J Osteoporos. 2013;2013:460210
pubmed: 23878759
J Bone Miner Res. 1997 Jul;12(7):1108-15
pubmed: 9200011
J Clin Endocrinol Metab. 2014 Nov;99(11):4315-20
pubmed: 25093620
J Am Soc Nephrol. 2003 Jun;14(6):1559-67
pubmed: 12761256
Plast Reconstr Surg. 2008 May;121(5):1554-1566
pubmed: 18453977
Am J Kidney Dis. 1998 Apr;31(4):607-17
pubmed: 9531176
Bone Miner. 1992 Nov;19(2):185-94
pubmed: 1422314
Front Physiol. 2021 Jan 05;11:511799
pubmed: 33584321
Kidney Int. 2016 Jul;90(1):77-89
pubmed: 27165819
Nat Rev Nephrol. 2010 Dec;6(12):723-35
pubmed: 20978469
Bone. 2018 Oct;115:50-58
pubmed: 28844835
J Endocrinol. 2021 Apr 23;249(2):R43-R51
pubmed: 33760754
Front Immunol. 2019 Jun 04;10:1278
pubmed: 31214203
J Bone Miner Res. 2021 Mar;36(3):510-522
pubmed: 33301619
Cells. 2021 Apr 24;10(5):
pubmed: 33923175
J Cell Physiol. 2008 Feb;214(2):537-44
pubmed: 17685428
JAMA. 1972 Mar 6;219(10):1307-11
pubmed: 5066773
Crit Rev Eukaryot Gene Expr. 2012;22(1):61-86
pubmed: 22339660
Nat Med. 2014 Nov;20(11):1270-8
pubmed: 25282358
J Am Soc Nephrol. 2005 Apr;16(4):917-28
pubmed: 15743994
Bone. 2003 Oct;33(4):673-84
pubmed: 14555273
Kidney Int. 2020 Dec;98(6):1461-1475
pubmed: 32721445
Arch Intern Med. 2007 May 14;167(9):879-85
pubmed: 17502528
Int J Mol Sci. 2020 Jun 18;21(12):
pubmed: 32570711
Clin Chim Acta. 2010 Oct 9;411(19-20):1412-20
pubmed: 20598675
Nephrol Dial Transplant. 2012 Jan;27(1):226-30
pubmed: 21613383
Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):1938-1966
pubmed: 31412740
Microcirculation. 2020 Jul;27(5):e12613
pubmed: 32065681
Z Kardiol. 2000;89 Suppl 2:101-4
pubmed: 10769411
Nature. 1986 Jun 19-25;321(6072):776-9
pubmed: 3012369
Am J Med Sci. 1999 Jun;317(6):370-6
pubmed: 10372836
Trends Mol Med. 2019 Dec;25(12):1133-1146
pubmed: 31522956
Bone. 2017 Jul;100:80-86
pubmed: 28119179
Trends Endocrinol Metab. 2021 Apr;32(4):238-256
pubmed: 33455863
Kidney Int. 1997 Nov;52(5):1232-41
pubmed: 9350646
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6199-204
pubmed: 23530237
Clin J Am Soc Nephrol. 2011 Apr;6(4):877-82
pubmed: 21164019
Nitric Oxide. 2018 Jun 1;76:62-70
pubmed: 29550520
J Orthop Translat. 2021 Jun 21;29:134-142
pubmed: 34249611
Int J Mol Sci. 2020 Nov 20;21(22):
pubmed: 33233840
Dev Cell. 2002 Apr;2(4):389-406
pubmed: 11970890
Bone. 2004 Feb;34(2):288-96
pubmed: 14962807
Nephrol Dial Transplant. 2020 Mar 1;35(Suppl 2):ii31-ii37
pubmed: 32162665
Calcif Tissue Int. 2021 Jul;109(1):66-76
pubmed: 33616712
Annu Rev Physiol. 2020 Feb 10;82:485-506
pubmed: 32040934
PLoS One. 2017 May 11;12(5):e0176411
pubmed: 28493902
Nature. 2014 Mar 20;507(7492):323-328
pubmed: 24646994
Nat Med. 2013 Feb;19(2):179-92
pubmed: 23389618
PLoS One. 2012;7(2):e30503
pubmed: 22355314
Circulation. 2005 Oct 25;112(17):2627-33
pubmed: 16246962
Toxins (Basel). 2019 Jul 21;11(7):
pubmed: 31330917
Int Urol Nephrol. 2016 Dec;48(12):2043-2050
pubmed: 27465794
Scand J Urol Nephrol. 1993;27(1):115-20
pubmed: 8493458
J Orthop Res. 2011 Mar;29(3):414-8
pubmed: 20939046
Clin Endocrinol (Oxf). 2012 Jun;76(6):797-801
pubmed: 22151063
Physiol Rev. 2012 Jan;92(1):131-55
pubmed: 22298654
PLoS One. 2018 Jan 5;13(1):e0190820
pubmed: 29304096
Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F477-91
pubmed: 26739890
J Clin Invest. 2021 Oct 15;131(20):
pubmed: 34437300
Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):475-80
pubmed: 19892583
Calcif Tissue Int. 2021 Apr;108(4):496-511
pubmed: 33586002
Kidney Int. 2017 Jun;91(6):1436-1446
pubmed: 28318623
Trends Endocrinol Metab. 2010 May;21(5):294-301
pubmed: 20079660
Circulation. 2021 Mar 16;143(11):1157-1172
pubmed: 33720773
Calcif Tissue Int. 2005 Sep;77(3):129-33
pubmed: 16151674
Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1926-31
pubmed: 10938013
Trends Mol Med. 2009 Sep;15(9):405-16
pubmed: 19733120
Nature. 1980 Nov 27;288(5789):373-6
pubmed: 6253831
J Clin Endocrinol Metab. 2012 Jun;97(6):2027-32
pubmed: 22466341
Cell. 2012 Jun 8;149(6):1192-205
pubmed: 22682243
Nephrol Dial Transplant. 2015 Aug;30(8):1345-56
pubmed: 25854266
Ther Adv Endocrinol Metab. 2021 Jun 25;12:20420188211025161
pubmed: 34262687
Z Kardiol. 2000;89 Suppl 2:63-8
pubmed: 10769405
Clin J Am Soc Nephrol. 2013 Dec;8(12):2132-40
pubmed: 24052218
Nephrol Dial Transplant. 2016 Feb;31(2):284-9
pubmed: 25832108
J Bone Miner Res. 1995 Mar;10(3):439-46
pubmed: 7540349
Plast Reconstr Surg. 2002 Jun;109(7):2384-97
pubmed: 12045566
Toxins (Basel). 2021 Jan 03;13(1):
pubmed: 33401534
Front Endocrinol (Lausanne). 2018 Jun 11;9:311
pubmed: 29942284
Nature. 1987 Jun 11-17;327(6122):524-6
pubmed: 3495737
BMC Nephrol. 2020 Dec 9;21(1):534
pubmed: 33297991
Nephrol Dial Transplant. 2011 Mar;26(3):1010-5
pubmed: 20709740
Exp Mol Med. 2016 Mar 11;48:e217
pubmed: 26964833
Adv Exp Med Biol. 2021;1303:333-350
pubmed: 33788201
Circ Res. 2006 Apr 14;98(7):905-12
pubmed: 16527991
Nature. 1986 Jun 19-25;321(6072):779-82
pubmed: 3086749
BMC Nephrol. 2013 Oct 10;14:219
pubmed: 24112318
J Biol Chem. 2001 Jun 8;276(23):20659-72
pubmed: 11274143
Kidney Int. 2019 Apr;95(4):958-972
pubmed: 30827513
Kidney Int. 2016 Jun;89(6):1231-43
pubmed: 27165838
Front Endocrinol (Lausanne). 2013 Aug 26;4:106
pubmed: 23986744
Cells. 2021 Jul 13;10(7):
pubmed: 34359937
Front Neurol. 2019 Aug 13;10:883
pubmed: 31456743
Curr Opin Nephrol Hypertens. 2020 Jul;29(4):367-377
pubmed: 32452917
Int J Nephrol. 2018 Sep 2;2018:9182078
pubmed: 30245880
J Clin Invest. 2012 Jul;122(7):2543-53
pubmed: 22728934
Calcif Tissue Int. 2012 Jun;90(6):473-80
pubmed: 22527202
PLoS One. 2018 Aug 3;13(8):e0201936
pubmed: 30075015
Cardiovasc Res. 2018 Mar 15;114(4):590-600
pubmed: 29514202
Cytokine Growth Factor Rev. 2021 Aug;60:1-17
pubmed: 33933900
N Engl J Med. 2000 May 4;342(18):1350-8
pubmed: 10793168
J Am Soc Nephrol. 2005 Feb;16(2):520-8
pubmed: 15615819
Kidney Int. 2006 Jun;69(11):1945-53
pubmed: 16641930
Mol Brain. 2019 Mar 25;12(1):23
pubmed: 30909971
J Bone Miner Res. 2015 Mar;30(3):499-509
pubmed: 25407607
Nat Med. 1999 Jun;5(6):623-8
pubmed: 10371499
Circulation. 2003 Oct 28;108(17):2154-69
pubmed: 14581387
Kidney Int. 2018 Jan;93(1):147-158
pubmed: 28843411
Calcif Tissue Int. 2007 May;80(5):301-6
pubmed: 17505774