Early Pupillometry Assessment in Traumatic Brain Injury Patients: A Retrospective Study.
outcome
prediction
pupillometry
traumatic brain injury
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
20 Dec 2021
20 Dec 2021
Historique:
received:
14
10
2021
revised:
06
12
2021
accepted:
13
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI). Retrospective observational study including adult (>18 years) TBI patients admitted from January 2018 to December 2020, with available NPi on admission. Abnormal NPi was considered if <3. Unfavorable neurological outcome (UO) at hospital discharge was considered for a Glasgow Outcome Scale of 1-3. 100 patients were included over the study period (median age 48 (34-69) years and median GCS on admission 11 (6-15)); 49 (49%) patients had UO. On admission, 20 (20%) patients had an abnormal NPi (NPi < 3); median worst (i.e., from both eyes) NPi was 4.2 (3.2-4.5). Median worst and mean NPi on admission were significantly lower in the UO group than others (3.9 (1.7-4.4) vs. 4.4 (3.7-4.6); Low NPi on admission has limited prognostic value in TBI.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI).
METHODS
METHODS
Retrospective observational study including adult (>18 years) TBI patients admitted from January 2018 to December 2020, with available NPi on admission. Abnormal NPi was considered if <3. Unfavorable neurological outcome (UO) at hospital discharge was considered for a Glasgow Outcome Scale of 1-3.
RESULTS
RESULTS
100 patients were included over the study period (median age 48 (34-69) years and median GCS on admission 11 (6-15)); 49 (49%) patients had UO. On admission, 20 (20%) patients had an abnormal NPi (NPi < 3); median worst (i.e., from both eyes) NPi was 4.2 (3.2-4.5). Median worst and mean NPi on admission were significantly lower in the UO group than others (3.9 (1.7-4.4) vs. 4.4 (3.7-4.6);
CONCLUSIONS
CONCLUSIONS
Low NPi on admission has limited prognostic value in TBI.
Identifiants
pubmed: 34942959
pii: brainsci11121657
doi: 10.3390/brainsci11121657
pmc: PMC8699519
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
World Neurosurg. 2021 Jan;145:e163-e169
pubmed: 33011358
J Neurotrauma. 2007 Feb;24(2):270-80
pubmed: 17375991
Neurology. 2000 Jan 25;54(2):530-1
pubmed: 10668738
Crit Care Med. 1998 Nov;26(11):1793-800
pubmed: 9824069
Intensive Care Med. 2018 Dec;44(12):2102-2111
pubmed: 30478620
J Neurotrauma. 2021 May 15;38(10):1411-1440
pubmed: 26537996
Crit Care. 2013 Jan 15;17(1):201
pubmed: 23320763
J Neurotrauma. 1992 Mar;9 Suppl 1:S287-92
pubmed: 1588618
J Korean Neurosurg Soc. 2015 Oct;58(4):363-7
pubmed: 26587191
Neurosurgery. 2017 Jan 01;80(1):6-15
pubmed: 27654000
Minerva Anestesiol. 2019 Sep;85(9):995-1002
pubmed: 30938123
Springerplus. 2014 Sep 23;3:548
pubmed: 25332854
Surg Neurol Int. 2011;2:82
pubmed: 21748035
Neurocrit Care. 2019 Aug;31(1):142-161
pubmed: 30484008
J Stat Softw. 2010;33(1):1-22
pubmed: 20808728
Intensive Care Med. 2014 Apr;40(4):484-95
pubmed: 24522878
J Intensive Care Med. 2021 Apr;36(4):383-391
pubmed: 31601157
Crit Care. 2019 May 2;23(1):155
pubmed: 31046817
Anesth Analg. 2015 Jun;120(6):1242-53
pubmed: 25988634
J Surg Res. 2021 Jun;262:27-37
pubmed: 33540153
J Neurotrauma. 2016 Oct 1;33(19):1768-1774
pubmed: 26866876
Intensive Care Med. 2016 Jan;42(1):3-15
pubmed: 26564211
J Trauma. 2006 Feb;60(2):274-8
pubmed: 16508482
PLoS Med. 2008 Aug 5;5(8):e165; discussion e165
pubmed: 18684008
Lancet. 1975 Mar 1;1(7905):480-4
pubmed: 46957
Chest. 2020 May;157(5):1167-1174
pubmed: 31870911
Neurosurg Rev. 2021 Oct;44(5):2697-2706
pubmed: 33340052
Crit Care. 2016 Mar 13;20:99
pubmed: 27072310