Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma.
asthma
exercise
inflammation
oxidative stress
reactive species interactome
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
30 Nov 2021
30 Nov 2021
Historique:
received:
26
10
2021
revised:
24
11
2021
accepted:
25
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Redox dysregulation and oxidative stress have been implicated in asthma pathogenesis. Exercise interventions improve symptoms and reduce inflammation in asthma patients, but the underlying mechanisms remain unclear. We hypothesized that a personalised exercise intervention would improve asthma control by reducing lung inflammation through modulation of local and systemic reactive species interactions, thereby increasing antioxidant capacity. We combined deep redox metabolomic profiling with clinical assessment in an exploratory cohort of six female patients with symptomatic asthma and studied their responses to a metabolically targeted exercise intervention over 12 weeks. Plasma antioxidant capacity and circulating nitrite levels increased following the intervention (
Identifiants
pubmed: 34943027
pii: antiox10121926
doi: 10.3390/antiox10121926
pmc: PMC8750917
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Respir Med. 2005 May;99(5):553-8
pubmed: 15823451
Cell. 2020 May 28;181(5):1112-1130.e16
pubmed: 32470399
Ann Allergy Asthma Immunol. 2014 Aug;113(2):137-42
pubmed: 24986036
Clin Respir J. 2008 Jul;2(3):166-74
pubmed: 20298325
Nitric Oxide. 2012 Aug 15;27(2):75-81
pubmed: 22609879
Respir Med. 2001 Aug;95(8):649-54
pubmed: 11530952
Eur Respir J. 2005 Sep;26(3):511-22
pubmed: 16135736
Antioxidants (Basel). 2017 Aug 10;6(3):
pubmed: 28796154
Allergol Int. 2021 Apr;70(2):181-189
pubmed: 33214087
J Biol Chem. 2008 Dec 5;283(49):33927-34
pubmed: 18835812
Nat Rev Drug Discov. 2008 Feb;7(2):156-67
pubmed: 18167491
Adv Microb Physiol. 2018;72:1-28
pubmed: 29778212
Respir Med. 2006 Apr;100(4):616-21
pubmed: 16226443
Anal Biochem. 2017 May 1;524:13-30
pubmed: 27789233
Antioxid Redox Signal. 2010 Jan;12(1):93-124
pubmed: 19634987
Am J Respir Crit Care Med. 1995 Jun;151(6):1725-33
pubmed: 7767513
Physiol Rev. 2008 Oct;88(4):1243-76
pubmed: 18923182
Nat Chem Biol. 2005 Oct;1(5):290-7
pubmed: 16408059
Redox Biol. 2020 Aug;35:101499
pubmed: 32192916
J Biol Chem. 1999 Sep 3;274(36):25933-44
pubmed: 10464338
BMC Pulm Med. 2019 May 24;19(1):99
pubmed: 31126281
Curr Opin Physiol. 2019 Jun;9:34-47
pubmed: 31417975
Antioxid Redox Signal. 2021 Nov 10;35(14):1226-1268
pubmed: 33985343
Br J Anaesth. 2015 Feb;114(2):244-51
pubmed: 25274049
Biochemistry. 2003 Feb 4;42(4):1150-9
pubmed: 12549937
Pulm Pharmacol Ther. 2021 Feb;66:101984
pubmed: 33338662
Redox Biol. 2019 Feb;21:101113
pubmed: 30738322
Chest. 1999 May;115(5):1265-70
pubmed: 10334138
J Allergy Clin Immunol. 2009 Jan;123(1):146-152.e8
pubmed: 19130935
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8665-70
pubmed: 19433800
PLoS One. 2012;7(12):e51185
pubmed: 23236449
Eur Respir J. 2020 Jul 30;56(1):
pubmed: 32350100
Redox Biol. 2020 Jun;33:101516
pubmed: 32249209
Redox Rep. 2003;8(1):57-63
pubmed: 12631446
Antioxid Redox Signal. 2005 May-Jun;7(5-6):547-59
pubmed: 15890000
Br J Sports Med. 2007 Oct;41(10):669-73; discussion 673
pubmed: 17496072
Free Radic Biol Med. 2002 Dec 1;33(11):1590-6
pubmed: 12446216
Sports Med. 2017 Feb;47(2):277-293
pubmed: 27260682
Redox Biol. 2016 Dec;10:191-199
pubmed: 27770706
Ann Allergy Asthma Immunol. 2004 Jul;93(1):91-7
pubmed: 15281477
Am J Physiol Cell Physiol. 2020 Feb 1;318(2):C304-C327
pubmed: 31693398
Cell Metab. 2015 Jul 7;22(1):4-11
pubmed: 26073496
Cell Rep. 2021 Apr 20;35(3):109018
pubmed: 33882313
Oxid Med Cell Longev. 2017;2017:6501046
pubmed: 28698768
J Endocrinol Invest. 2021 May;44(5):1119-1122
pubmed: 32885340
Behav Res Methods. 2013 Sep;45(3):792-812
pubmed: 23184532
Biochem Res Int. 2016;2016:3757623
pubmed: 27064342
PeerJ. 2020 May 19;8:e9230
pubmed: 32477840
J Asthma. 2005 Feb;42(1):45-50
pubmed: 15801328
Acta Oncol. 2019 May;58(5):588-595
pubmed: 30724668
Med Sci Sports Exerc. 2021 Feb 1;53(2):280-294
pubmed: 32735111
Redox Biol. 2018 Jun;16:359-380
pubmed: 29627744
Cardiovasc Res. 2020 Jan 1;116(1):51-62
pubmed: 31372656
Oxid Med Cell Longev. 2016;2016:2840643
pubmed: 27974950
Br J Anaesth. 2009 Oct;103(4):505-10
pubmed: 19628486
Hypertens Res. 2004 Dec;27(12):947-53
pubmed: 15894835
J Allergy Clin Immunol. 2015 Aug;136(2):454-61.e9
pubmed: 25748343
Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1865-79
pubmed: 16987039
Pediatr Res. 2011 Feb;69(2):154-9
pubmed: 20975618
Front Immunol. 2021 Mar 24;12:653969
pubmed: 33868294
Pediatr Pulmonol. 2006 Oct;41(10):929-36
pubmed: 16871619
J Clin Endocrinol Metab. 2002 Oct;87(10):4496-501
pubmed: 12364425
Am J Respir Crit Care Med. 2006 Jun 1;173(11):1186-93
pubmed: 16528016
FASEB J. 2002 Nov;16(13):1775-85
pubmed: 12409320
J Intern Med. 2005 Oct;258(4):328-35
pubmed: 16164571
Pharmacol Res. 2016 Sep;111:452-458
pubmed: 27378569
Front Sports Act Living. 2021 Nov 26;3:782590
pubmed: 34901852
Nitric Oxide. 2016 May 1;55-56:54-61
pubmed: 27000467
J Allergy Clin Immunol. 2011 Jun;127(6):1604-11
pubmed: 21514635
Br J Anaesth. 2018 Mar;120(3):484-500
pubmed: 29452805
Respir Med. 2011 Jul;105(7):1007-13
pubmed: 21277184
Redox Biol. 2021 May;41:101907
pubmed: 33667994
Asthma Res Pract. 2020 Jun 9;6:5
pubmed: 32537235
Life Sci. 2001 Jul 20;69(9):1005-16
pubmed: 11508642
J Allergy Clin Immunol Pract. 2020 Nov - Dec;8(10):3396-3406.e4
pubmed: 32544545
BMC Pulm Med. 2013 Jun 13;13:38
pubmed: 23758826
Eur Respir J. 2005 Sep;26(3):523-48
pubmed: 16135737
Antioxid Redox Signal. 2017 Oct 1;27(10):684-712
pubmed: 28398072
Antioxidants (Basel). 2020 Jul 23;9(8):
pubmed: 32717801
J Vis Exp. 2020 May 12;(159):
pubmed: 32478759