Riboceine Rescues Auranofin-Induced Craniofacial Defects in Zebrafish.
Riboceine
antioxidant
auranofin
craniofacial anomalies
neural crest
oxidative stress
zebrafish
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
08 Dec 2021
08 Dec 2021
Historique:
received:
08
11
2021
revised:
04
12
2021
accepted:
06
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Craniofacial abnormalities are a common group of congenital developmental disorders that can require intensive oral surgery as part of their treatment. Neural crest cells (NCCs) contribute to the facial structures; however, they are extremely sensitive to high levels of oxidative stress, which result in craniofacial abnormalities under perturbed developmental environments. The oxidative stress-inducing compound auranofin (AFN) disrupts craniofacial development in wildtype zebrafish embryos. Here, we tested whether the antioxidant Riboceine (RBC) rescues craniofacial defects arising from exposure to AFN. RBC rescued AFN-induced cellular apoptosis and distinct defects of the cranial cartilage in zebrafish larvae. Zebrafish embryos exposed to AFN have higher expression of antioxidant genes
Identifiants
pubmed: 34943067
pii: antiox10121964
doi: 10.3390/antiox10121964
pmc: PMC8750187
pii:
doi:
Types de publication
Journal Article
Langues
eng
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