Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors.
CRP and IL-6
Kyn/Trp
Phe/Tyr
frailty
modifiable risk factors
neopterin
nitrite
oxi-immune markers
oxidative DNA damage
vitamin A and vitamin E
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
10 Dec 2021
10 Dec 2021
Historique:
received:
11
10
2021
revised:
22
11
2021
accepted:
02
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Ageing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalisation, and death in older adults. The aim of this study was to understand the relationship between frailty syndrome, immune activation, and oxidative stress. Serum concentrations of vitamins A and E were also evaluated, as well as inflammatory biomarkers (CRP and IL-6) and oxidative DNA levels. A group of Portuguese older adults (≥65 years old) was engaged in this study and classified according to Fried's frailty phenotype. Significant increases in the inflammatory mediators (CRP and IL-6), neopterin levels, kynurenine to tryptophan ratio (Kyn/Trp), and phenylalanine to tyrosine ratio (Phe/Tyr), and significant decreases in Trp and Tyr concentrations were observed in the presence of frailty. IL-6, neopterin, and Kyn/Trp showed potential as predictable biomarkers of frailty syndrome. Several clinical parameters such as nutrition, dependency scales, and polypharmacy were related to frailty and, consequently, may influence the associations observed. Results obtained show a progressive immune activation and production of pro-inflammatory molecules in the presence of frailty, agreeing with the inflammageing model. Future research should include different dimensions of frailty, including psychological, social, biological, and environmental factors.
Identifiants
pubmed: 34943076
pii: antiox10121975
doi: 10.3390/antiox10121975
pmc: PMC8750623
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fundação para a Ciência e Tecnologia
ID : SFRH/BD/121802/2016
Organisme : Fundação para a Ciência e Tecnologia
ID : SFRH/BPD/115112/2016
Organisme : Fundação para a Ciência e Tecnologia
ID : SFRH/BPD/100948/2014
Organisme : Ministerio de Ciencia e Innovación
ID : PID2020-113788RB-I00
Organisme : Ministerio de Educación Cultura y Deporte
ID : BEAGAL18/00142
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