Itch in Adult Population with Type 2 Diabetes Mellitus: Clinical Profile, Pathogenesis and Disease-Related Burden in a Cross-Sectional Study.
diabetic itch
pruritus
type 2 diabetes mellitus
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
15 Dec 2021
15 Dec 2021
Historique:
received:
21
11
2021
revised:
09
12
2021
accepted:
10
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Despite growing interest in itch, data regarding itch in type 2 diabetes mellitus (DM2) are still limited, and mostly based on outdated studies. This study aimed to evaluate the clinical characteristics of itch in the adult population with DM2 and explore potential underlying causes. The study group consisted of 109 adult patients with DM2. Standardized questionnaires were completed in order to assess the itch intensity [Numerical Rating Scale (three days, 24hours) (NRS)] and the Four-item Itch Questionnaire (4IIQ) and to assess the psychological impact of itch [ItchyQoL, Six-Item Stigmatization Scale (6-ISS), Hospital Anxiety and Depression Scale (HADS)]. Skin dryness was evaluated clinically and by non-invasive assessment of epidermis moisturizing. Neuropathy was assessed using the clinical Katzenwadel neuropathy scale. Itch occurred in 35.8% of adult patients with DM2, with NRS We suggest that the primary cause of itch is prolonged poor diabetes control with altered glucose and insulin levels, subsequently causing skin dryness and neuropathy in long-lasting DM2.
Sections du résumé
BACKGROUND
BACKGROUND
Despite growing interest in itch, data regarding itch in type 2 diabetes mellitus (DM2) are still limited, and mostly based on outdated studies. This study aimed to evaluate the clinical characteristics of itch in the adult population with DM2 and explore potential underlying causes.
METHODS
METHODS
The study group consisted of 109 adult patients with DM2. Standardized questionnaires were completed in order to assess the itch intensity [Numerical Rating Scale (three days, 24hours) (NRS)] and the Four-item Itch Questionnaire (4IIQ) and to assess the psychological impact of itch [ItchyQoL, Six-Item Stigmatization Scale (6-ISS), Hospital Anxiety and Depression Scale (HADS)]. Skin dryness was evaluated clinically and by non-invasive assessment of epidermis moisturizing. Neuropathy was assessed using the clinical Katzenwadel neuropathy scale.
RESULTS
RESULTS
Itch occurred in 35.8% of adult patients with DM2, with NRS
CONCLUSIONS
CONCLUSIONS
We suggest that the primary cause of itch is prolonged poor diabetes control with altered glucose and insulin levels, subsequently causing skin dryness and neuropathy in long-lasting DM2.
Identifiants
pubmed: 34943248
pii: biology10121332
doi: 10.3390/biology10121332
pmc: PMC8698455
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Science and Higher Education
ID : 016/RID/2018/19.
Références
Dermatol Ther (Heidelb). 2020 Aug;10(4):745-756
pubmed: 32514836
Acta Derm Venereol. 2019 Apr 1;99(5):469-506
pubmed: 30931482
Int J Dermatol. 2019 Mar;58(3):273-278
pubmed: 30039870
Lancet Neurol. 2012 Jun;11(6):521-34
pubmed: 22608666
Eur J Dermatol. 2013 Sep-Oct;23(5):688-93
pubmed: 24001954
Int J Clin Pharmacol Ther. 2005 Feb;43(2):71-7
pubmed: 15726875
J Invest Dermatol. 2000 Jul;115(1):24-9
pubmed: 10886503
J Eur Acad Dermatol Venereol. 2016 Jul;30(7):1159-64
pubmed: 27027485
J Neuroimmunol. 2021 Jun 15;355:577574
pubmed: 33894676
Diabetologia. 1984 Feb;26(2):93-8
pubmed: 6370764
Diabetes Care. 2020 Jan;43(Suppl 1):S14-S31
pubmed: 31862745
Med J Malaysia. 2021 Sep;76(5):643-652
pubmed: 34508369
Acta Derm Venereol. 2018 Jan 12;98(1):142-143
pubmed: 28853494
Br J Dermatol. 2005 Aug;153(2):319-23
pubmed: 16086742
J Eur Acad Dermatol Venereol. 2019 Feb;33(2):391-397
pubmed: 30193410
Lancet Neurol. 2018 Aug;17(8):709-720
pubmed: 30033061
Curr Opin Neurol. 2012 Oct;25(5):542-9
pubmed: 22941266
Med Sci Monit. 2019 Jan 04;25:115-120
pubmed: 30609422
Korean J Intern Med. 2020 Nov;35(6):1507-1516
pubmed: 32450676
J Eur Acad Dermatol Venereol. 2021 Mar;35(3):738-743
pubmed: 32924186
Diabetes Care. 2010 Jan;33(1):150-5
pubmed: 20040674
JAMA Dermatol. 2014 Jun;150(6):613-20
pubmed: 24671747
Diabet Med. 1985 Sep;2(5):383-6
pubmed: 2951095
Acta Derm Venereol. 2017 Jun 9;97(6):759-760
pubmed: 28224165
Microvasc Res. 2012 Mar;83(2):243-8
pubmed: 21722653
Diabetes Res Clin Pract. 2018 Apr;138:271-281
pubmed: 29496507
Diabetologia. 2005 Feb;48(2):210-4
pubmed: 15650820
Acta Derm Venereol. 2015 Jan;95(1):114-5
pubmed: 24816723
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
Front Med (Lausanne). 2021 Feb 24;8:641746
pubmed: 33732722
Acta Derm Venereol. 2020 Feb 5;100(4):adv00051
pubmed: 31993670
Acta Derm Venereol. 2007;87(4):291-4
pubmed: 17598029
J Clin Neuromuscul Dis. 2001 Dec;3(2):47-52
pubmed: 19078654
J Pain Symptom Manage. 2018 May;55(5):e4-e7
pubmed: 29382542
J Indian Med Assoc. 1989 Jun;87(6):138-9
pubmed: 2584730
Acta Derm Venereol. 2015 Apr;95(4):417-21
pubmed: 25203328
Diabetes Care. 2020 Jan;43(Suppl 1):S135-S151
pubmed: 31862754
Diabetes Care. 1986 May-Jun;9(3):273-5
pubmed: 3731993
J Invest Dermatol. 2003 Jan;120(1):79-85
pubmed: 12535201
Front Med (Lausanne). 2021 Jan 20;7:615334
pubmed: 33553209
J Eur Acad Dermatol Venereol. 2015 Aug;29(8):1631-5
pubmed: 25178455
J Pak Med Assoc. 1998 Oct;48(10):304-5
pubmed: 10087751
J Eur Acad Dermatol Venereol. 2020 Aug;34(8):1795-1802
pubmed: 31838774
Lancet. 2010 Jun 26;375(9733):2215-22
pubmed: 20609967
Acta Derm Venereol. 2018 Feb 7;98(2):185-190
pubmed: 28971208
Diabetes Care. 2016 Nov;39(11):1987-1995
pubmed: 27493134
Diabetes. 1989 Nov;38(11):1456-61
pubmed: 2620781
J Dtsch Dermatol Ges. 2006 Apr;4(4):350-70
pubmed: 16638066